Does evaluation of tumour budding in diagnostic biopsies have a clinical relevance? A systematic review

被引:33
作者
Almangush, Alhadi [1 ,2 ,3 ]
Youssef, Omar [1 ]
Pirinen, Matti [4 ,5 ,6 ]
Sundstrom, Jari [2 ]
Leivo, Ilmo [2 ]
Makitie, Antti A. [7 ,8 ,9 ]
机构
[1] Univ Helsinki, Dept Pathol, Helsinki, Finland
[2] Univ Turku, Inst Biomed, Pathol, Turku, Finland
[3] Univ Misurata, Inst Dent, Misurata, Libya
[4] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland
[5] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
[6] Univ Helsinki, Dept Math & Stat, Helsinki, Finland
[7] HUS Helsinki Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland
[8] Univ Helsinki, Haartmaninkatu 3,POB 21, FIN-00014 Helsinki, Finland
[9] Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Ear Nose & Throat Dis, Stockholm, Sweden
关键词
biopsy; marker; prognosis; treatment planning; tumour budding; SQUAMOUS-CELL CARCINOMA; LYMPH-NODE METASTASIS; PREOPERATIVE BIOPSIES; PROGNOSTIC VALUE; POOR-PROGNOSIS; CANCER; STAGE; PREDICTS; SPECIMENS; TONGUE;
D O I
10.1111/his.13793
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Tumour budding has emerged as a promising prognostic marker in many cancers. We systematically reviewed all studies that evaluated tumour budding in diagnostic biopsies. We conducted a systematic review of PubMed, MEDLINE, Scopus, Web of Science and Cochrane library for all articles that have assessed tumour budding in diagnostic (i.e. pretreatment or pre-operative) biopsies of any tumour type. Two independent researchers screened the retrieved studies, removed duplicates, excluded irrelevant studies and extracted data from the eligible studies. A total of 13 reports comprising 11 cohorts were found to have studied tumour budding in diagnostic biopsies. All these reports showed that evaluation of tumour budding in diagnostic biopsies was easily applicable. A strong association was observed between tumour budding score in diagnostic biopsies and corresponding surgical samples. Evaluation of tumour budding in diagnostic biopsies had a significant prognostic value for lymph node metastasis and patient survival. In all studies, tumour budding was a valuable marker of tumour aggressiveness and can be evaluated in technically satisfactory diagnostic biopsies. Thus, the assessment of tumour budding seems to identify the behaviour of cancer, and therefore to facilitate treatment planning.
引用
收藏
页码:536 / 544
页数:9
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