Nanostructured Fibers Containing Natural or Synthetic Bioactive Compounds in Wound Dressing Applications

被引：30

作者：

Croitoru, Alexa-Maria ^{[1
]}

Ficai, Denisa ^{[1
]}

Ficai, Anton ^{[1
,2
]}

Mihailescu, Natalia ^{[3
]}

Andronescu, Ecaterina ^{[1
,2
]}

Turculet, Claudiu Florin ^{[4
,5
]}

机构：

[1] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Gh Polizu St 1-7, Bucharest 011061, Romania

[2] Acad Romanian Scientists, Spl Independentei 54, Bucharest 050094, Romania

[3] Natl Inst Laser Plasma & Radiat Phys, Laser Dept, Atomistilor St 409, Magurele 077125, Romania

[4] Carol Davila Univ Med & Pharm, Fac Med, Eroii Sanitari St 8, Bucharest 050474, Romania

[5] Emergency Hosp Floreasca Bucharest, Calea Floreasca St 8, Bucharest 014461, Romania

来源：

MATERIALS | 2020年 / 13卷 / 10期

关键词：

electrospinning; electrospun nanofibers; wound dressing; natural; synthetic substances; DRUG-DELIVERY; CONTROLLED-RELEASE; ELECTROSPUN NANOFIBERS; NONWOVEN MATS; IN-VITRO; CHITOSAN; ANTIBACTERIAL; FABRICATION; OXIDE; ACID;

D O I：

10.3390/ma13102407

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The interest in wound healing characteristics of bioactive constituents and therapeutic agents, especially natural compounds, is increasing because of their therapeutic properties, cost-effectiveness, and few adverse effects. Lately, nanocarriers as a drug delivery system have been actively investigated and applied in medical and therapeutic applications. In recent decades, researchers have investigated the incorporation of natural or synthetic substances into novel bioactive electrospun nanofibrous architectures produced by the electrospinning method for skin substitutes. Therefore, the development of nanotechnology in the area of dressings that could provide higher performance and a synergistic effect for wound healing is needed. Natural compounds with antimicrobial, antibacterial, and anti-inflammatory activity in combination with nanostructured fibers represent a future approach due to the increased wound healing process and regeneration of the lost tissue. This paper presents different approaches in producing electrospun nanofibers, highlighting the electrospinning process used in fabricating innovative wound dressings that are able to release natural and/or synthetic substances in a controlled way, thus enhancing the healing process.

引用

页数：19

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