Development and characterization of molecularly imprinted polymers for controlled release of citalopram

被引：40

作者：

Abdouss, Majid ^{[1
]}

Asadi, Ebadullah ^{[1
]}

Azodi-Deilami, Saman ^{[1
]}

Beik-mohammadi, Neda ^{[1
]}

Aslanzadeh, Saeed Amir ^{[2
]}

机构：

[1] Amir Kabir Univ Technol, Dept Chem, Tehran, Iran

[2] Enghelab Islami Tech Coll, Tehran, Iran

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2011年 / 22卷 / 10期

关键词：

SOLID-PHASE EXTRACTION; SOFT CONTACT-LENSES; PRECIPITATION POLYMERIZATION; LIQUID-CHROMATOGRAPHY; CONTROLLED DELIVERY; DRUG-DELIVERY; BETA-BLOCKERS; RECOGNITION; TRAMADOL;

D O I：

10.1007/s10856-011-4395-3

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this work, the use of molecularly imprinted polymers (MIPs) for citalolpram as anti-depressant drug was studied. Imprinted polymers were prepared from methacrylic acid (MAA; functional monomer), ethylene glycol dimethacrylate (EGDMA; cross-linker), and citalopram (as a drug template) using bulk polymerization method. The polymeric devices were further characterized by FT-IR, thermogravimetric analysis, scanning electron microscopy, and binding experiments. The dissolution media employed in controlled release studies were hydrochloric acid at the pH level of 4.3 and phosphate buffers, at pH levels of 7.2 and 10.1, maintained at 37.0 and 25.0 +/- A 0.5A degrees C. Results showed the ability of MIP polymers to control the release of citalopram. In all cases, the imprinted polymers showed a higher affinity for citalopram and a slower release rate than the nonimprinted polymers. At the pH level of 4.3 and at the temperature of 25A degrees C, slower release of citalopram imprinted polymer occurred.

引用

页码：2273 / 2281

页数：9

共 32 条

[31] Voltammetric behaviour of bromhexine and its determination in pharmaceuticals [J].