The world according to Hedgehog

被引：466
作者：
Hammerschmidt, M
Brook, A
McMahon, AP
机构：
[1] MASSACHUSETTS GEN HOSP,CTR CANC,MOL ONCOL LAB,CHARLESTOWN,MA 02129
[2] HARVARD UNIV,DEPT MOL & CELLULAR BIOL,BIOLABS,CAMBRIDGE,MA 02138
来源：
TRENDS IN GENETICS | 1997年 / 13卷 / 01期
关键词：
D O I：
10.1016/S0168-9525(96)10051-2
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Members of the Hedgebog family of signaling molecules mediate many important short- and long-range patterning processes during invertebrate and vertebrate development. In the fly, a single hedgebog gene regulates segmental and imaginal disc patterning. In contrast, in vertebrates a hedgebog gene family is involved in the control of left-right asymmetry, polarity in the central nervous system (CNS), somites and limb, organogenesis, chondrogenesis and spermatogenesis. Here, we review experiments addressing the function of the various Hedgebog members during invertebrate and vertebrate development.
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页码：14 / 21
页数：8
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