Adventitial Biology Differentiation and Function

被引：85

作者：

Hu, Yanhua ^{[1
]}

Xu, Qingbo ^{[1
]}

机构：

[1] Kings Coll London, Div Cardiovasc, British Heart Fdn, London SE5 9NU, England

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2011年 / 31卷 / 07期

关键词：

vascular progenitors; stem cells; angiogenesis; restenosis; vascular biology; ENDOTHELIAL PROGENITOR CELLS; SMOOTH-MUSCLE-CELLS; CYTOKINE-INDUCED MOBILIZATION; VASA-VASORUM; VASCULAR CALCIFICATION; BONE-MARROW; VESSEL WALL; NEOINTIMAL FORMATION; SONIC HEDGEHOG; ARTERIAL-WALL;

D O I：

10.1161/ATVBAHA.110.221176

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent evidence indicates that stem/progenitor cells are present in the adventitia and participate in vascular repair and the formation of neointimal lesions in severely damaged vessels. Data have also demonstrated that these resident stem/progenitor cells could differentiate into endothelial or smooth muscle cells in response to different stimuli. Under pathological conditions, adventitial inflammation results in releasing a panel of cytokines, such as stromal cell-derived factor-1 and tumor necrosis factor-alpha, that may lead to local stem/progenitor mobilization and differentiation. Overall, these data support the impact of the adventitial progenitors in pathophysiological processes of lesion development in the arterial wall. In the present review, we aim to summarize the data concerning the presence of the resident stem cells and discuss the pathological impact of the adventitia in vascular diseases. We will also discuss the possible signal pathways orchestrating stem cell differentiation toward vascular lineage and highlight controversial issues related to the role of adventitial progenitors. (Arterioscler Thromb Vasc Biol. 2011; 31:1523-1529.)

引用

页码：1523 / 1529

页数：7

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