Potential of a glucagon-like peptide-1 receptor/glucose-dependent insulinotropic polypeptide receptor/glucagon receptor triagonist for the treatment of obesity and type 2 diabetes

被引：1

作者：

Araki, Eiichi ^{[1
,2
]}

Sakaguchi, Masaji ^{[1
]}

Fukuda, Kazuki ^{[1
,2
]}

Kondo, Tatsuya ^{[1
]}

机构：

[1] Kumamoto Univ, Fac Life Sci, Dept Metab Med, Kumamoto, Japan

[2] Kumamoto Univ, Fac Life Sci, Ctr Metab Regulat Hlth Aging, Kumamoto, Japan

来源：

JOURNAL OF DIABETES INVESTIGATION | 2022年

关键词：

DUAL GIP; GLP-1; AGONIST; WEIGHT;

D O I：

10.1111/jdi.13896

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：3

共 9 条

[1] Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist [J].

Bossart, Martin ;

Wagner, Michael ;

Elvert, Ralf ;

Evers, Andreas ;

Hubschle, Thomas ;

Kloeckener, Tim ;

Lorenz, Katrin ;

Moessinger, Christine ;

Eriksson, Olof ;

Velikyan, Irina ;

Pierrou, Stefan ;

Johansson, Lars ;

Dietert, Gabriele ;

Dietz-Baum, Yasmin ;

Kissner, Thomas ;

Nowotny, Irene ;

Einig, Christine ;

Jan, Christelle ;

Rharbaoui, Faiza ;

Gassenhuber, Johann ;

Prochnow, Hans-Peter ;

Agueusop, Inoncent ;

Porksen, Niels ;

Smith, William B. ;

Nitsche, Almut ;

Konkar, Anish .

CELL METABOLISM, 2022, 34 (01) :59-+

[2] Glucose-Dependent Insulinotropic Polypeptide (GIP) Inhibits Bone Resorption Independently of Insulin and Glycemia [J].

Christensen, Mikkel B. ;

Lund, Asger ;

Calanna, Salvatore ;

Jorgensen, Niklas R. ;

Holst, Jens J. ;

Vilsboll, Tina ;

Knop, Filip K. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2018, 103 (01) :288-294

[3] LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept [J].

Coskun, Tamer ;

Sloop, Kyle W. ;

Loghin, Corina ;

Alsina-Fernandez, Jorge ;

Urva, Shweta ;

Bokvist, Krister B. ;

Cui, Xuewei ;

Briere, Daniel A. ;

Cabrera, Over ;

Roell, William C. ;

Kuchibhotla, Uma ;

Moyers, Julie S. ;

Benson, Charles T. ;

Gimeno, Ruth E. ;

D'Alessio, David A. ;

Haupt, Axel .

MOLECULAR METABOLISM, 2018, 18 :3-14

[4] Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1 [J].

Drucker, Daniel J. .

CELL METABOLISM, 2018, 27 (04) :740-756

[5] Running on mixed fuel-dual agonistic approach of GLP-1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non-human primates [J].

Elvert, Ralf ;

Herling, Andreas W. ;

Bossart, Martin ;

Weiss, Tilo ;

Zhang, Baohong ;

Wenski, Pierre ;

Wandschneider, Joern ;

Kleutsch, Sabrina ;

Butty, Uwe ;

Kannt, Aimo ;

Wagner, Michael ;

Haack, Torsten ;

Evers, Andreas ;

Dudda, Angela ;

Lorenz, Martin ;

Keil, Stefanie ;

Larsen, Philip J. .

DIABETES OBESITY & METABOLISM, 2018, 20 (08) :1836-1851

[6] Team Players or Opponents: Coadministration of Selective Glucagon and GLP-1 Receptor Agonists in Obese Diabetic Monkeys [J].

Elvert, Ralf ;

Bossart, Martin ;

Herling, Andreas W. ;

Weiss, Tilo ;

Zhang, Baohong ;

Kannt, Aimo ;

Wagner, Michael ;

Haack, Torsten ;

Evers, Andreas ;

Dudda, Angela ;

Keil, Stefanie ;

Lorenz, Martin ;

Lorenz, Katrin ;

Riz, Michela ;

Hennerici, Wolfgang ;

Larsen, Philip J. .

ENDOCRINOLOGY, 2018, 159 (08) :3105-3119

[7] A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents [J].

Finan, Brian ;

Yang, Bin ;

Ottaway, Nickki ;

Smiley, David L. ;

Ma, Tao ;

Clemmensen, Christoffer ;

Chabenne, Joe ;

Zhang, Lianshan ;

Habegger, Kirk M. ;

Fischer, Katrin ;

Campbell, Jonathan E. ;

Sandoval, Dar Leen ;

Seeley, Randy J. ;

Bleicher, Konrad ;

Uhles, Sabine ;

Riboulet, William ;

Funk, Jurgen ;

Hertel, Cornelia ;

Belli, Sara ;

Sebokova, Elena ;

Conde-Knape, Karin ;

Konkar, Anish ;

Drucker, Daniel J. ;

Gelfanov, Vasily ;

Pfluger, Paul T. ;

Muller, Timo D. ;

Perez-Tilve, Diego ;

DiMarchi, Richard D. ;

Tschop, Matthias H. .

NATURE MEDICINE, 2015, 21 (01) :27-36

[8] Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes [J].

Frias, Juan P. ;

Davies, Melanie J. ;

Rosenstock, Julio ;

Manghi, Federico C. Perez ;

Lando, Laura Fernandez ;

Bergman, Brandon K. ;

Liu, Bing ;

Cui, Xuewei ;

Brown, Katelyn .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (06) :503-515

[9] Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial [J].

Rosenstock, Julio ;

Wysham, Carol ;

Frias, Juan P. ;

Kaneko, Shizuka ;

Lee, Clare J. ;

Lando, Laura Fernandez ;

Mao, Huzhang ;

Cui, Xuewei ;

Karanikas, Chrisanthi A. ;

Thieu, Vivian T. .

LANCET, 2021, 398 (10295) :143-155

← 1 →