Targeting neurodegeneration to prevent post-traumatic epilepsy

被引：25
作者：
Ali, Idrish [1 ,2 ]
Silva, Juliana C. [1 ,2 ]
Liu, Shijie [1 ,2 ]
Shultz, Sandy R. [1 ,2 ]
Kwan, Patrick [1 ,2 ]
Jones, Nigel C. [1 ,2 ]
O'Brien, Terence J. [1 ,2 ]
机构：
[1] Monash Univ, Alfred Hosp, Cent Clin Sch, Dept Neurosci, Melbourne, Vic, Australia
[2] Univ Melbourne, Royal Melbourne Hosp, Dept Med, Melbourne, Vic, Australia
来源：
NEUROBIOLOGY OF DISEASE | 2019年 / 123卷
关键词：
Neurodegeneration; Tauopathies; beta amyloid; Neuroinflammation; Traumatic brain injury; Post-traumatic epilepsy; TRAUMATIC BRAIN-INJURY; AMYLOID PRECURSOR PROTEIN; MICROTUBULE-ASSOCIATED PROTEIN-2; CEREBROSPINAL-FLUID BIOMARKERS; MILD COGNITIVE IMPAIRMENT; TAU TRANSGENIC MICE; ALZHEIMERS-DISEASE; SODIUM SELENATE; MOUSE MODEL; STATUS EPILEPTICUS;
D O I：
10.1016/j.nbd.2018.08.006
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In the quest for developing new therapeutic targets for post-traumatic epilepsies (PTE), identifying mechanisms relevant to development and progression of disease is critical. A growing body of literature suggests involvement of neurodegenerative mechanisms in the pathophysiology of acquired epilepsies, including following traumatic brain injury (TBI). In this review, we discuss the potential of some of these mechanisms to be targets for the development of a therapy against PTE.
引用
收藏
页码：100 / 109
页数：10
相关论文
共 157 条
[1]   HOW IMPORTANT IS ALZHEIMER'S DISEASE AS A RISK FACTOR FOR UNPROVOKED SEIZURES AND EPILEPSY IN THE ELDERLY? [J].
Abou-Khalil, Bassel W. .
EPILEPSY CURRENTS, 2010, 10 (02) :36-37
[2]   Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype [J].
Aboud, Orwa ;
Mrak, Robert E. ;
Boop, Frederick A. ;
Griffin, W. Sue T. .
ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2013, 1
[3]   Progress in neuroprotective strategies for preventing epilepsy [J].
Acharya, Munjal M. ;
Hattiangady, Bharathi ;
Shetty, Ashok K. .
PROGRESS IN NEUROBIOLOGY, 2008, 84 (04) :363-404
[4]   Concise Review: Prospects of Bone Marrow Mononuclear Cells and Mesenchymal Stem Cells for Treating Status Epilepticus and Chronic Epilepsy [J].
Agadi, Satish ;
Shetty, Ashok K. .
STEM CELLS, 2015, 33 (07) :2093-2103
[5]   Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae [J].
Albayram, Onder ;
Kondo, Asami ;
Mannix, Rebekah ;
Smith, Colin ;
Tsai, Cheng-Yu ;
Li, Chenyu ;
Herbert, Megan K. ;
Qiu, Jianhua ;
Monuteaux, Michael ;
Driver, Jane ;
Yan, Sandra ;
Gormley, William ;
Puccio, Ava M. ;
Okonkwo, David O. ;
Lucke-Wold, Brandon ;
Bailes, Julian ;
Meehan, William ;
Zeidel, Mark ;
Lu, Kun Ping ;
Zhou, Xiao Zhen .
NATURE COMMUNICATIONS, 2017, 8
[6]   Decreased post-synaptic density-95 protein expression on dendrites of newborn neurons following CX3CR1 modulation in the epileptogenic adult rodent brain [J].
Ali, Idrish ;
Avdic, Una ;
Chugh, Deepti ;
Ekdahl, Christine T. .
CELLULAR & MOLECULAR IMMUNOLOGY, 2018, 15 (04) :414-417
[7]   Intracerebral delivery of the M2 polarizing cytokine interleukin 13 using mesenchymal stem cell implants in a model of temporal lobe epilepsy in mice [J].
Ali, Idrish ;
Aertgeerts, Stephanie ;
Le Blon, Debbie ;
Bertoglio, Daniele ;
Hoornaert, Chloe ;
Ponsaerts, Peter ;
Dedeurwaerdere, Stefanie .
EPILEPSIA, 2017, 58 (06) :1063-1072
[8]   Incidence and predictors of seizures in patients with Alzheimer's disease [J].
Amatniek, JC ;
Hauser, WA ;
DelCastillo-Castaneda, C ;
Jacobs, DM ;
Marder, K ;
Bell, K ;
Albert, M ;
Brandt, J ;
Stern, Y .
EPILEPSIA, 2006, 47 (05) :867-872
[9]   P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy [J].
Amhaoul, Halima ;
Ali, Idrish ;
Mola, Marco ;
Van Eetveldt, Annemie ;
Szewczyk, Krystyna ;
Missault, Stephan ;
Bielen, Kenny ;
Kumar-Singh, Samir ;
Rech, Jason ;
Lord, Brian ;
Ceusters, Marc ;
Bhattacharya, Anindya ;
Dedeurwaerdere, Stefanie .
NEUROPHARMACOLOGY, 2016, 105 :175-185
[10]  
An SJ, 2003, MOL CELLS, V15, P200
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