Opponent appetitive-aversive neural processes underlie predictive learning of pain relief

被引:311
作者
Seymour, B
O'Doherty, JP
Koltzenburg, M
Wiech, K
Frackowiak, R
Friston, KJ
Dolan, R
机构
[1] Wellcome Dept Imaging Neurosci, London WC1N 3BG, England
[2] CALTECH, Div Humanities & Social Sci 228 77, Pasadena, CA 91125 USA
[3] UCL, Inst Child Hlth, London WC1N 1EH, England
[4] Fdn Santa Lucia, Neuroimaging Lab, I-00179 Rome, Italy
基金
英国惠康基金;
关键词
D O I
10.1038/nn1527
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Termination of a painful or unpleasant event can be rewarding. However, whether the brain treats relief in a similar way as it treats natural reward is unclear, and the neural processes that underlie its representation as a motivational goal remain poorly understood. We used fMRI ( functional magnetic resonance imaging) to investigate how humans learn to generate expectations of pain relief. Using a pavlovian conditioning procedure, we show that subjects experiencing prolonged experimentally induced pain can be conditioned to predict pain relief. This proceeds in a manner consistent with contemporary reward-learning theory ( average reward/loss reinforcement learning), reflected by neural activity in the amygdala and midbrain. Furthermore, these reward-like learning signals are mirrored by opposite aversion-like signals in lateral orbitofrontal cortex and anterior cingulate cortex. This dual coding has parallels to 'opponent process' theories in psychology and promotes a formal account of prediction and expectation during pain.
引用
收藏
页码:1234 / 1240
页数:7
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