Expression of Olfactory-Related Genes in the Olfactory Epithelium of an Alzheimer's Disease Mouse Model

被引：1

作者：

Narukawa, Masataka ^{[1
]}

Mori, Yuko ^{[1
]}

Nishida, Riko ^{[1
]}

Takahashi, Suzuka ^{[2
]}

Saito, Takashi ^{[3
,4
]}

Saido, Takaomi C. ^{[3
]}

Misaka, Takumi ^{[2
]}

机构：

[1] Kyoto Womens Univ, Dept Food & Nutr, Kyoto, Japan

[2] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Tokyo, Japan

[3] RIKEN, Lab Proteolyt Neurosci, Ctr Brain Sci, Saitama, Japan

[4] Nagoya City Univ, Inst Brain Sci, Dept Neurocognit Sci, Grad Sch Med Sci, Nagoya, Aichi, Japan

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2022年 / 88卷 / 01期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

App knock-in mice; olfactory epithelium; olfactory impairment; olfactory related genes; DYSFUNCTION; IMPAIRMENT;

D O I：

10.3233/JAD-220213

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using an amyloid precursor protein (App) gene knock-in (KI) mouse of Alzheimer's disease (AD), we investigated the expression of olfactory-related genes in olfactory impairment caused by AD. We observed the change in olfactory behavior in the App-KI mice. There was no significant difference, however, in the mRNA expression levels of olfactory-related genes between the olfactory epithelia of wild-type (WT) and App-KI mice. Amyloid-beta deposition was confirmed throughout the olfactory pathway in App-KI mice, but not in WT mice. These show that the change in olfactory behavior in the App-KI mice might cause by the impairment of the olfactory pathway.

引用

页码：29 / 35

页数：7

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