Frailty: An emerging research and clinical paradigm - Issues and controversies

被引：819

作者：

Bergman, Howard ^{[1
]}

Ferrucci, Luigi ^{[2
]}

Guralnik, Jack ^{[3
]}

Hogan, David B. ^{[4
]}

Hummel, Silvia ^{[5
]}

Karunananthan, Sathya ^{[5
]}

Wolfson, Christina ^{[6
]}

机构：

[1] McGill Univ, Jewish Gen Hosp, Div Geriatr Med, Montreal, PQ H3T 1E2, Canada

[2] NIA, Clin Res Branch, Baltimore, MD 21224 USA

[3] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA

[4] Univ Calgary, Div Geriatr Med, Calgary, AB T2N 1N4, Canada

[5] McGill Univ Montreal, Solidage Res Grp, Canadian Initiat Frailty & Aging, Jewish Gen Hosp, Quebec City, PQ, Canada

[6] McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ, Canada

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2007年 / 62卷 / 07期

关键词：

D O I：

10.1093/gerona/62.7.731

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Clinicians and researchers have shown increasing interest in frailty. Yet, there is still considerable uncertainty regarding the concept and its definition. In this article, we present perspectives on key issues and controversies discussed by scientists from 13 different countries, representing a diverse range of disciplines, at the 2006 Second International Working Meeting on Frailty and Aging. The following fundamental questions are discussed: What is the distinction, if any, between frailty and aging? What is its relationship with chronic disease? Is frailty a syndrome or a series of age-related impairments that predict adverse outcomes? What are the critical domains in its operational definition? Is frailty a useful concept? The implications of different models and approaches are examined. Although consensus has yet to be attained, work accomplished to date has opened exciting new horizons. The article concludes with suggested directions for future research.

引用

页码：731 / 737

页数：7

共 70 条

[21] Living with the past: Evolution, development, and patterns of disease [J].