Functional precision oncology: Testing tumors with drugs to identify vulnerabilities and novel combinations

被引：153

作者：

Letai, Anthony ^{[1
,2
]}

Bhola, Patrick ^{[2
,3
]}

Welm, Alana L. ^{[4
]}

机构：

[1] Dana Farber Canc Inst, Boston, MA 02215 USA

[2] Harvard Med Sch, Boston, MA 02215 USA

[3] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[4] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

来源：

CANCER CELL | 2022年 / 40卷 / 01期

关键词：

CHEMOTHERAPY SENSITIVITY; AMERICAN-SOCIETY; OPEN-LABEL; CANCER; XENOGRAFTS; RESISTANCE; MEDICINE; THERAPY; GROWTH; RESPONSES;

D O I：

10.1016/j.ccell.2021.12.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Functional precision medicine is a strategy whereby live tumor cells from affected individuals are directly perturbed with drugs to provide immediately translatable, personalized information to guide therapy. The heterogeneity of human cancer has led to the realization that personalized approaches are needed to improve treatment outcomes. Precision oncology has traditionally used static features of the tumor to dictate which therapies should be used. Static features can include expression of key targets or genomic analysis of mutations to identify therapeutically targetable "drivers."Although a surprisingly small proportion of individuals derive clinical benefit from the static approach, functional precision medicine can provide additional information regarding tumor vulnerabilities. We discuss emerging technologies for functional precision medicine as well as limitations and challenges in using these assays in the clinical trials that will be necessary to determine whether functional precision medicine can improve outcomes and eventually become a standard tool in clinical oncology.

引用

页码：26 / 35

页数：10

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