Effects of curcumin on hypoxia-inducible factor as a new therapeutic target

被引：50

作者：

Bahrami, Afsane ^{[1
]}

Atkin, Stephen L. ^{[2
]}

Majeed, Muhammed ^{[3
]}

Sahebkar, Amirhossein ^{[4
,5
,6
]}

机构：

[1] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran

[2] Weill Cornell Med Qatar, Doha, Qatar

[3] Sabina Corp, East Windsor, NJ USA

[4] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran

[5] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran

[6] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran

来源：

PHARMACOLOGICAL RESEARCH | 2018年 / 137卷

关键词：

Aryl hydrocarbon receptor nuclear translocator; Hypoxia-responsive elements; Turmeric; Von Hippel-Lindau; RECEPTOR NUCLEAR TRANSLOCATOR; ENDOPLASMIC-RETICULUM STRESS; EPITHELIAL-MESENCHYMAL TRANSITION; RANDOMIZED CONTROLLED-TRIAL; SYSTEMIC OXIDATIVE STRESS; GROWTH-FACTOR EXPRESSION; FATTY LIVER-DISEASE; QUALITY-OF-LIFE; NF-KAPPA-B; FACTOR-I;

D O I：

10.1016/j.phrs.2018.10.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that consists of two subunits, the HIF-1 alpha and HIF-1 beta (ARNT). Under hypoxic conditions, HIF-1 is an adaptive system that regulates the transcription of multiple genes associated with growth, angiogenesis, proliferation, glucose transport, metabolism, pH regulation and cell death. However, aberrant HIF-1 activation contributes to the pathophysiology of several human diseases such as cancer, ischemic cardiovascular disorders, and pulmonary and kidney diseases. A growing body of evidence indicates that curcumin, a natural bioactive compound of turmeric root, significantly targets both HIF-1 subunits, but is more potent against HIF-1 alpha. In this review, we have summarized the knowledge about the pharmacological effects of curcumin on HIF-1 and the related molecular mechanisms that may be effective candidates for the development of multi-targeted therapy for several human diseases.

引用

页码：159 / 169

页数：11

共 162 条

[51] Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1 [J].