Bacterial protein toxins that modify host regulatory GTPases

被引：215

作者：

Aktories, Klaus ^{[1
]}

机构：

[1] Univ Freiburg, Inst Expt & Klin Pharmakol & Toxikol, D-79104 Freiburg, Germany

来源：

NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 07期

关键词：

PASTEURELLA-MULTOCIDA TOXIN; CYTOTOXIC NECROTIZING FACTOR; CLOSTRIDIUM-DIFFICILE TOXIN; NUCLEOTIDE-EXCHANGE FACTOR; SORDELLII LETHAL TOXIN; BORDETELLA DERMONECROTIC TOXIN; HETEROTRIMERIC G-PROTEINS; ADP-RIBOSYLATING TOXINS; III SECRETION SYSTEM; GTP-BINDING PROTEINS;

D O I：

10.1038/nrmicro2592

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Many bacterial pathogens produce protein toxins to outmanoeuvre the immune system of the host. Some of these proteins target regulatory GTPases such as those belonging to the RHO family, which control the actin cytoskeleton of the host cell. In this Review, I discuss a diversity of mechanisms that are used by bacterial effectors and toxins to modulate the activity of host GTPases, with a focus on covalent modifications such as ADP-ribosylation, glucosylation, adenylylation, proteolysis, deamidation and transglutamination.

引用

页码：487 / 498

页数：12

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