Oral Lichen Planus and Oral Squamous Cell Carcinoma share key oncogenic signatures

被引：14

作者：

de lanna, Cristovao Antunes ^{[1
]}

Monteiro da Silva, Beatriz Nascimento ^{[2
]}

de Melo, Andreia Cristina ^{[2
]}

Bonamino, Martin H. ^{[3
,4
]}

Borges Alves, Lisia Daltro ^{[2
]}

Ribeiro Pinto, Luis Felipe ^{[5
]}

Cardoso, Abel Silveira ^{[6
]}

Antunes, Heliton Spindola ^{[2
]}

Boroni, Mariana ^{[1
,7
]}

Goldemberg, Daniel Cohen ^{[2
,8
]}

机构：

[1] Brazilian Natl Canc Inst INCA, Div Expt & Translat Res, Lab Bioinformat & Computat Biol, BR-20231050 Rio De Janeiro, Brazil

[2] Natl Canc Inst Jose Alencar Gomes Silva INCA, Div Clin Res & Technol Dev, Rio De Janeiro, RJ, Brazil

[3] Brazilian Natl Canc Inst INCA, Immunol & Tumor Biol Program Res Coordinat, Rio De Janeiro, Brazil

[4] Oswaldo Cruz Fdn FIOCRUZ, Presidency Res & Biol Collect VPPCB, Rio De Janeiro, Brazil

[5] Brazilian Natl Canc Inst INCA, Mol Carcinogenesis Program, Rio De Janeiro, Brazil

[6] Univ Fed Rio Janeiro, Sch Dent, Dept Oral Pathol & Oral Diag, Rio De Janeiro, Brazil

[7] Univ Campinas UNICAMP, Expt Med Res Cluster EMRC, BR-13083970 Campinas, Brazil

[8] Univ Coll London UCL, Latin Amer Cooperat Oncol Grp LACOG Head & Neck, London, England

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

MALIGNANT-TRANSFORMATION; EXPRESSION; CANCER; PATHWAY; GROWTH; ASSOCIATION; BIOMARKERS; DISCOVERY; INVASION; PACKAGE;

D O I：

10.1038/s41598-022-24801-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To investigate similarities in the gene profile of Oral Lichen Planus and Oral Squamous Cell Carcinoma that may justify a carcinogenic potential, we analyzed the gene expression signatures of Oral Lichen Planus and Oral Squamous Cell Carcinoma in early and advanced stages. Based on gene expression data from public databases, we used a bioinformatics approach to compare expression profiles, estimate immune infiltrate composition, identify differentially and co-expressed genes, and propose putative therapeutic targets and associated drugs. Our results revealed gene expression patterns related to processes of keratinization, keratinocyte differentiation, cell proliferation and immune response in common between Oral Lichen Planus and early and advanced Oral Squamous Cell Carcinoma, with the cornified envelope formation and antigen processing cross-presentation pathways in common between Oral Lichen Planus and early Oral Squamous Cell Carcinoma. Together, these results reveal that key tumor suppressors and oncogenes such as PI3, SPRR1B and KRT17, as well as genes associated with different immune processes such as CXCL13, HIF1A and IL1B are dysregulated in OLP.

引用

页数：12

共 75 条

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