How do you RUN on?

被引：8

作者：

Yoshida, Hitomi ^{[1
]}

Kitagishi, Yasuko ^{[1
]}

Okumura, Naoko ^{[1
]}

Murakami, Mutsumi ^{[1
]}

Nishimura, Yuri ^{[1
]}

Matsuda, Satoru ^{[1
]}

机构：

[1] Nara Womens Univ, Dept Environm Hlth Sci, Nara 630, Japan

来源：

FEBS LETTERS | 2011年 / 585卷 / 12期

关键词：

RUN domain; Rab; Rap; Small GTPase; Motor protein; Actin filament; TUMOR-SUPPRESSOR; SUBCELLULAR-LOCALIZATION; CAENORHABDITIS-ELEGANS; INTERACTING PROTEIN; BINDING PARTNER; CELL MIGRATION; MYOSIN-VI; TRANSPORT; DOMAIN; MERLIN;

D O I：

10.1016/j.febslet.2011.05.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RUN domain is present in several proteins related to the functions of Rap and Rab family GTPases. Accumulating evidence supports the hypothesis that RUN domain-containing proteins act as a component of vesicle traffic and might be responsible for an interaction with a filamentous network linked to actin cytoskeleton or microtubules. That is to say, on one hand, RUN domains associate with Rab or Rap family proteins, on the other hand, they also might interact with motor proteins such as kinesin or myosin via intervention molecules. In this review, we summarize the background and current status of RUN domain research with an emphasis on the interaction between RUN domain and motor proteins with respect to the vesicle traffic on filamentous network. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1707 / 1710

页数：4

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