Two-Photon-Induced Microstereolithography of Chitosan-g-Oligolactides as a Function of Their Stereochemical Composition

被引:27
作者
Demina, Tatiana S. [1 ]
Bardakova, Kseniia N. [2 ,3 ]
Minaev, Nikita V. [2 ]
Svidchenko, Eugenia A. [1 ]
Istomin, Alexander V. [1 ]
Goncharuk, Galina P. [1 ]
Vladimirov, Leonid V. [4 ]
Grachev, Andrey V. [4 ]
Zelenetskii, Alexander N. [1 ]
Timashev, Peter S. [2 ,3 ]
Akopova, Tatiana A. [1 ]
机构
[1] Russian Acad Sci, Enikolopov Inst Synthet Polymer Mat, 70 Profsoyuznaya Str, Moscow 117393, Russia
[2] Russian Acad Sci, Inst Photon Technol, Res Ctr Crystallog & Photon, 2 Pionerskaya Str, Moscow 142190, Russia
[3] Sechenov Univ, Inst Regenerat Med, 8-2 Trubetskaya St, Moscow 119991, Russia
[4] Russian Acad Sci, Semenov Inst Chem Phys, 4 Kosygina Str, Moscow 119334, Russia
基金
俄罗斯基础研究基金会; 俄罗斯科学基金会;
关键词
laser stereolithography; chitosan; lactide; mechanochemistry; two-photon polymerization; graft-copolymers; hydrogels; HYDROGELS; POLYMERIZATION; DERIVATIVES; FABRICATION;
D O I
10.3390/polym9070302
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Chitosan-g-oligolactide copolymers with relatively long oligolactide grafted chains of various stereochemical compositions have been synthetized via a solvent-free mechanochemical technique and tailored to fabricate three-dimensional hydrogels using two-photon induced microstereolithography. An effect of the characteristics of chitosan and oligolactide used for the synthesis on the grafting yield and copolymer's behavior were evaluated using fractional analysis, FTIR-spectroscopy, dynamic light scattering, and UV-spectrophotometry. The lowest copolymer yield was found for the system based on chitosan with higher molecular weight, while the samples consisting of low-molecular weight chitosan showed higher grafting degrees, which were comparable in both the cases of L, L-or L, D-oligolactide grafting. The copolymer processability in the course of two-photon stereolithography was evaluated as a function of the copolymer's characteristics and stereolithography conditions. The structure and mechanical properties of the model film samples and fabricated 3D hydrogels were studied using optical and scanning electron microscopy, as well as by using tensile and nanoindenter devices. The application of copolymer with oligo(L, D-lactide) side chains led to higher processability during two-photon stereolithography in terms of the response to the laser beam, reproduction of the digital model, and the mechanical properties of the fabricated hydrogels.
引用
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页数:14
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