Association between TNFSF10 polymorphism and migraine susceptibility in a Chinese population

被引：5

作者：

Jia, Shasha ^{[1
]}

Dong, Wanli ^{[2
]}

Zhou, Xianju ^{[1
]}

Chen, Zhiguo ^{[1
]}

Yun, Wenwei ^{[1
]}

机构：

[1] Nanjing Med Univ, Changzhou Peoples Hosp 2, Affiliated Hosp, Dept Neurol,Lab Neurol Dis, Changzhou 213003, Jiangsu, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Dept Neurol, Suzhou, Peoples R China

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2015年 / 43卷 / 03期

关键词：

Migraine; TNFSF10; gene polymorphisms; susceptibility; TUMOR-NECROSIS-FACTOR; PREVALENCE; RECEPTORS; HEADACHE; BURDEN;

D O I：

10.1177/0300060514565681

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective To investigate the correlation between migraine in a Chinese population and a 4 base pair (GAGT) insertion/deletion polymorphism (rs35975099) localized near the 3' end of the tumour necrosis factor superfamily 10 gene, TNFSF10. Methods Ethnically Han Chinese patients with migraine and healthy control subjects were recruited. TNFSF10 genotype and allele frequencies were determined via polymerase chain reaction and polyacrylamide gel electrophoresis. Results Rs35975099 was in Harvey-Weinberg equilibrium in patients with migraine (n=269) and control subjects (n=374). There were no significant relationships between allele or genotype frequency and migraine. Conclusion There was no functional significance of the TNFSF10 gene polymorphism rs35975099 in migraine pathogenesis.

引用

页码：326 / 331

页数：6

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