Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target

被引:19
作者
Mai, Shaoshan [1 ]
Inkielewicz-Stepniak, Iwona [1 ]
机构
[1] Med Univ Gdansk, Dept Pharmaceut Pathophysiol, Fac Pharm, Gdansk, Poland
基金
欧盟地平线“2020”;
关键词
pancreatic cancer; platelets; TCIPA; platelet-derived factors; platelet extracellular vesicles; angiogenesis; organoids; biomarker; ENDOTHELIAL GROWTH-FACTOR; TISSUE FACTOR ACTIVITY; REDUCES TUMOR-GROWTH; P-SELECTIN; PROSTATE-CANCER; COLORECTAL-CANCER; DUCTAL ADENOCARCINOMAS; KINASE INHIBITOR; ANIMAL-MODELS; SOLID TUMORS;
D O I
10.3389/fcell.2021.749689
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Platelets have been recognized as key players in hemostasis, thrombosis, and cancer. Preclinical and clinical researches evidenced that tumorigenesis and metastasis can be promoted by platelets through a wide variety of crosstalk between cancer cells and platelets. Pancreatic cancer is a devastating disease with high morbidity and mortality worldwide. Although the relationship between pancreatic cancer and platelets in clinical diagnosis is described, the interplay between pancreatic cancer and platelets, the underlying pathological mechanism and pathways remain a matter of intensive study. This review summaries recent researches in connections between platelets and pancreatic cancer. The existing data showed different underlying mechanisms were involved in their complex crosstalk. Typically, pancreatic tumor accelerates platelet aggregation which forms thrombosis. Furthermore, extracellular vesicles released by platelets promote communication in a neoplastic microenvironment and illustrate how these interactions drive disease progression. We also discuss the advantages of novel model organoids in pancreatic cancer research. A more in-depth understanding of tumor and platelets crosstalk which is based on organoids and translational therapies may provide potential diagnostic and therapeutic strategies for pancreatic cancer progression.
引用
收藏
页数:13
相关论文
共 212 条
[1]   The plasminogen activation system in tumor growth, invasion, and metastasis [J].
Andreasen, PA ;
Egelund, R ;
Petersen, HH .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2000, 57 (01) :25-40
[2]   The Role of Soluble CD40L Ligand in Human Carcinogenesis [J].
Angelou, Anastasios ;
Antoniou, Efstathios ;
Garmpis, Nikolaos ;
Damaskos, Christos ;
Theocharis, Stamatios ;
Margonis, Georgios-Antonios .
ANTICANCER RESEARCH, 2018, 38 (05) :3199-3201
[3]  
ASSOIAN RK, 1983, J BIOL CHEM, V258, P7155
[4]   P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment [J].
Azab, Abdel Kareem ;
Quang, Phong ;
Azab, Feda ;
Pitsillides, Costas ;
Thompson, Brian ;
Chonghaile, Triona ;
Patton, John T. ;
Maiso, Patricia ;
Monrose, Val ;
Sacco, Antonio ;
Ngo, Hai T. ;
Flores, Ludmila M. ;
Lin, Charles P. ;
Magnani, John L. ;
Kung, Andrew L. ;
Letai, Anthony ;
Carrasco, Ruben ;
Roccaro, Aldo M. ;
Ghobrial, Irene M. .
BLOOD, 2012, 119 (06) :1468-1478
[5]   Platelet and osteoclast β3 integrins are critical for bone metastasis [J].
Bakewell, SJ ;
Nestor, P ;
Prasad, S ;
Tomasson, MH ;
Dowland, N ;
Mehrotra, M ;
Scarborough, R ;
Kanter, J ;
Abe, K ;
Phillips, D ;
Weilbaecher, KN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (24) :14205-14210
[6]   Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in platelets [J].
Becker, Katrin Anne ;
Beckmann, Nadine ;
Adams, Constantin ;
Hessler, Gabriele ;
Kramer, Melanie ;
Gulbins, Erich ;
Carpinteiro, Alexander .
CLINICAL & EXPERIMENTAL METASTASIS, 2017, 34 (01) :25-35
[7]   Pancreatic cancer models for translational research [J].
Behrens, Diana ;
Walther, Wolfgang ;
Fichtner, Iduna .
PHARMACOLOGY & THERAPEUTICS, 2017, 173 :146-158
[8]   PDGFR-induced autocrine SDF-1 signaling in cancer cells promotes metastasis in advanced skin carcinoma [J].
Bernat-Peguera, Adria ;
Simon-Extremera, Pilar ;
da Silva-Diz, Victoria ;
Lopez de Munain, Mikel ;
Diaz-Gil, Laura ;
Penin, Rosa M. ;
Gonzalez-Suarez, Eva ;
Sidelnikova, Diana Perez ;
Bermejo, Oriol ;
Vinals, Joan Maria ;
Vinals, Francesc ;
Munoz, Purificacion .
ONCOGENE, 2019, 38 (25) :5021-5037
[9]   RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics [J].
Best, Myron G. ;
Sol, Nik ;
Kooi, Irsan ;
Tannous, Jihane ;
Westerman, Bart A. ;
Rustenburg, Francois ;
Schellen, Pepijn ;
Verschueren, Heleen ;
Post, Edward ;
Koster, Jan ;
Ylstra, Bauke ;
Ameziane, Najim ;
Dorsman, Josephine ;
Smit, Egbert F. ;
Verheul, Henk M. ;
Noske, David P. ;
Reijneveld, Jaap C. ;
Nilsson, R. Jonas A. ;
Tannous, Bakhos A. ;
Wesseling, Pieter ;
Wurdinger, Thomas .
CANCER CELL, 2015, 28 (05) :666-676
[10]   Global Conservation of Protein Status between Cell Lines and Xenografts [J].
Biau, Julian ;
Chautard, Emmanuel ;
Court, Frank ;
Pereira, Bruno ;
Verrelle, Pierre ;
Devun, Flavien ;
De Koning, Leanne ;
Dutreix, Marie .
TRANSLATIONAL ONCOLOGY, 2016, 9 (04) :313-321