Bacterial toxins in musculoskeletal infections

被引：9

作者：

Saeed, Kordo ^{[1
]}

Sendi, Parham ^{[2
,3
]}

Arnold, William, V ^{[4
]}

Bauer, Thomas W. ^{[5
]}

Coraca-Huber, Debora C. ^{[6
]}

Chen, Antonia F. ^{[7
]}

Choe, Hyonmin ^{[8
]}

Daiss, John L. ^{[9
]}

Ghert, Michelle ^{[10
]}

Hickok, Noreen J. ^{[11
]}

Nishitani, Kohei ^{[12
]}

Springer, Bryan D. ^{[13
]}

Stoodley, Paul ^{[14
,15
,16
,17
]}

Sculco, Thomas P. ^{[18
]}

Brause, Barry D. ^{[19
]}

Parvizi, Javad ^{[20
]}

McLaren, Alex C. ^{[21
]}

Schwarz, Edward M. ^{[22
]}

机构：

[1] Univ Southampton, Univ Hosp Southampton NHS Fdn Trust, Dept Microbiol, MIRU,Sch Med, Tremona Rd, Southampton SO16 6YD, Hants, England

[2] Univ Bern, Inst Infect Dis, Bern, Switzerland

[3] Univ Basel, Univ Hosp Basel, Dept Infect Dis & Hosp Epidemiol, Dept Orthopaed & Traumatol, Basel, Switzerland

[4] Thomas Jefferson Univ Hosp, Dept Orthopaed Surg, Rothman Inst, Philadelphia, PA 19107 USA

[5] Hosp Special Surg, Weill Cornell Med Coll, Dept Pathol & Lab Med, 535 E 70th St, New York, NY 10021 USA

[6] Med Univ Innsbruck, Dept Orthopaed Surg, Res Lab Implant Associated Infect, Expt Orthopaed,Biofilm Lab, Innsbruck, Austria

[7] Harvard Med Sch, Dept Orthopaed Surg, Brigham & Womens Hosp, Boston, MA 02115 USA

[8] Yokohama City Univ, Dept Orthopaed Surg, Yokohama, Kanagawa, Japan

[9] Univ Rochester, Sch Med & Dent, Ctr Musculoskeletal Res, Rochester, NY USA

[10] McMaster Univ, Dept Surg, Div Orthopaed Surg, Hamilton, ON, Canada

[11] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Orthopaed Surg, Philadelphia, PA 19107 USA

[12] Kyoto Univ, Dept Orthopaed Surg, Kyoto, Japan

[13] OrthoCarolina Hip & Knee Ctr, Atrium Musculoskeletal Inst, Charlotte, NC USA

[14] Ohio State Univ, Dept Microbial Infect, Columbus, OH 43210 USA

[15] Ohio State Univ, Dept Immun, Columbus, OH 43210 USA

[16] Ohio State Univ, Orthoped Infect Dis Inst, Columbus, OH 43210 USA

[17] Univ Southampton, Natl Ctr Microbial Tribol Southampton nCATS, NBIC, Mech Engn, Southampton, Hants, England

[18] Hosp Special Surg, Weill Cornell Med, Dept Orthopaed Surg, 535 E 70th St, New York, NY 10021 USA

[19] Hosp Special Surg, Weill Cornell Med, Dept Infect Dis, 535 E 70th St, New York, NY 10021 USA

[20] Thomas Jefferson Univ Hosp, Dept Orthopaed, Rothman Inst, Philadelphia, PA 19107 USA

[21] Univ Arizona, Coll Med Phoenix, Dept Orthopaed Surg, Phoenix, AZ USA

[22] Univ Rochester, Ctr Musculoskeletal Res, Dept Orthopaed, Rochester, NY USA

来源：

JOURNAL OF ORTHOPAEDIC RESEARCH | 2021年 / 39卷 / 02期

基金：

美国国家卫生研究院; 英国生物技术与生命科学研究理事会;

关键词：

bacterial toxins; biofilm meeting; musculoskeletal infection (MSKI); PJI; Staphylococcus; virulence factors; STAPHYLOCOCCUS-AUREUS BIOFILMS; PANTON-VALENTINE LEUKOCIDIN; ANTIBODY-SECRETING CELLS; PHENOL-SOLUBLE MODULINS; SYNOVIAL-FLUID; RTX TOXIN; VIRULENCE; INTERLEUKIN-6; EXPRESSION; PIGMENT;

D O I：

10.1002/jor.24683

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Musculoskeletal infections (MSKIs) remain a major health burden in orthopaedics. Bacterial toxins are foundational to pathogenesis in MSKI, but poorly understood by the community of providers that care for patients with MSKI, inducing an international group of microbiologists, infectious diseases specialists, orthopaedic surgeons and biofilm scientists to review the literature in this field to identify key topics and compile the current knowledge on the role of toxins in MSKI, with the goal of illuminating potential impact on biofilm formation and dispersal as well as therapeutic strategies. The group concluded that further research is needed to maximize our understanding of the effect of toxins on MSKIs, including: further research to identify the roles of bacterial toxins in MSKIs, establish the understanding of the importance of environmental and host factors and in vivo expression of toxins throughout the course of an infection, establish the principles of drug-ability of antitoxins as antimicrobial agents in MSKIs, have well-defined metrics of success for antitoxins as antiinfective drugs, design a cocktail of antitoxins against specific pathogens to (a) inhibit biofilm formation and (b) inhibit toxin release. (i)(ii)(iii)(iv)(v) The applicability of antitoxins as potential antimicrobials in the era of rising antibiotic resistance could meet the needs of day-to-day clinicians.

引用

页码：240 / 250

页数：11

共 70 条

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