The biological underpinnings of therapeutic resistance in pancreatic cancer

被引：82

作者：

Beatty, Gregory L. ^{[1
,2
,3
]}

Werba, Gregor ^{[4
,5
]}

Lyssiotis, Costas A. ^{[6
,7
,8
]}

Simeone, Diane M. ^{[4
,5
,9
]}

机构：

[1] Abramson Canc Ctr, Philadelphia, PA 19104 USA

[2] Univ Penn, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Med, Div Hematol Oncol, Perelman Sch Med, Philadelphia, PA 19104 USA

[4] NYU, Dept Surg, Sch Med, New York, NY 10016 USA

[5] NYU, Langone Med Ctr, Perlmutter Canc Ctr, 550 1St Ave, New York, NY 10016 USA

[6] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA

[7] Univ Michigan, Dept Internal Med, Div Gastroenterol & Hepatol, Ann Arbor, MI 48109 USA

[8] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA

[9] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA

来源：

GENES & DEVELOPMENT | 2021年 / 35卷 / 13-14期

关键词：

genetics; metabolism; microbiome; PDAC; pancreatic cancer; pancreatic tumor microenvironment; targeted therapy; therapeutic resistance; ONCOGENIC KRAS; T-CELLS; DUCTAL ADENOCARCINOMA; SOLID TUMORS; DNA-REPAIR; PHASE-II; PHYSICAL BARRIERS; SINGLE-CENTER; MOUSE MODEL; OPEN-LABEL;

D O I：

10.1101/gad.348523.121

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in the United States and has only recently achieved a 5-yr survival rate of 10%. This dismal prognosis reflects the remarkable capacity of PDAC to effectively adapt to and resist therapeutic intervention. In this review, we discuss recent advances in our understanding of the biological underpinnings of PDAC and their implications as targetable vulnerabilities in this highly lethal disease.

引用

页码：940 / +

页数：24

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