Development of a Compton camera for prompt-gamma medical imaging

被引：42

作者：

Aldawood, S. ^{[1
,2
]}

Thirolf, P. G. ^{[1
]}

Miani, A. ^{[1
,3
]}

Boehmer, M. ^{[4
]}

Dedes, G. ^{[1
]}

Gernhauser, R. ^{[4
]}

Lang, C. ^{[1
]}

Liprandi, S. ^{[1
]}

Maier, L. ^{[4
]}

Marinsek, T. ^{[1
]}

Mayerhofer, M. ^{[1
]}

Schaart, D. R. ^{[5
]}

Lozano, I. Valencia ^{[1
]}

Parodi, K. ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Dept Med Phys, Fak Phys, Coulombwall 1, Garching, Germany

[2] King Saud Univ, Dept Phys & Astron, Riyadh, Saudi Arabia

[3] Univ Milan, Milan, Italy

[4] Tech Univ Munich, Garching, Germany

[5] Delft Univ Technol, Delft, Netherlands

来源：

RADIATION PHYSICS AND CHEMISTRY | 2017年 / 140卷

关键词：

Compton camera; Prompt-gamma imaging; Hadron therapy; Scintillation detectors; RANGE VERIFICATION; PET DETECTORS; PROTON-BEAMS; THERAPY; SIMULATION;

D O I：

10.1016/j.radphyschem.2017.01.024

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A Compton camera-based detector system for photon detection from nuclear reactions induced by proton (or heavier ion) beams is under development at LMU Munich, targeting the online range verification of the particle beam in hadron therapy via prompt-gamma imaging. The detector is designed to be capable to reconstruct the photon source origin not only from the Compton scattering kinematics of the primary photon, but also to allow for tracking of the secondary Compton-scattered electrons, thus enabling a gamma-source reconstruction also from incompletely absorbed photon events. The Compton camera consists of a monolithic LaBr3:Ce scintillation crystal, read out by a multi-anode PMT acting as absorber, preceded by a stacked array of 6 double-sided silicon strip detectors as scatterers. The detector components have been characterized both under offline and online conditions. The LaBr3:Ce crystal exhibits an excellent time and energy resolution. Using intense collimated Cs-137 and Co-60 sources, the monolithic scintillator was scanned on a fine 2D grid to generate a reference library of light amplitude distributions that allows for reconstructing the photon interaction position using a k-Nearest Neighbour (k-NN) algorithm. Systematic studies were performed to investigate the performance of the reconstruction algorithm, revealing an improvement of the spatial resolution with increasing photon energy to an optimum value of 3.7(1)mm at 1.33 MeV, achieved with the Categorical Average Pattern (CAP) modification of the k-NN algorithm.

引用

页码：190 / 197

页数：8

共 29 条

[21] Design Guidelines for a Double Scattering Compton Camera for Prompt-γ Imaging During Ion Beam Therapy: A Monte Carlo Simulation Study [J].

Richard, M. -H. ;

Chevallier, M. ;

Dauvergne, D. ;

Freud, N. ;

Henriquet, P. ;

Le Foulher, F. ;

Letang, J. M. ;

Montarou, G. ;

Ray, C. ;

Roellinghoff, F. ;

Testa, E. ;

Testa, M. ;

Walenta, A. H. .

IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2011, 58 (01) :87-94

[22] Real-time proton beam range monitoring by means of prompt-gamma detection with a collimated camera [J].

Roellinghoff, F. ;

Benilov, A. ;

Dauvergne, D. ;

Dedes, G. ;

Freud, N. ;

Janssens, G. ;

Krimmer, J. ;

Letang, J. M. ;

Pinto, M. ;

Prieels, D. ;

Ray, C. ;

Smeets, J. ;

Stichelbaut, F. ;

Testa, E. .

PHYSICS IN MEDICINE AND BIOLOGY, 2014, 59 (05) :1327-1338

[23]

Santiard J.-C., 1994, CERNECP9417

[24] Real-time monitoring of the Bragg-peak position in ion therapy by means of single photon detection [J].

Testa, M. ;

Bajard, M. ;

Chevallier, M. ;

Dauvergne, D. ;

Freud, N. ;

Henriquet, P. ;

Karkar, S. ;

Le Foulher, F. ;

Letang, J. M. ;

Plescak, R. ;

Ray, C. ;

Richard, M. -H. ;

Schardt, D. ;

Testa, E. .

RADIATION AND ENVIRONMENTAL BIOPHYSICS, 2010, 49 (03) :337-343

[25] A Compton camera prototype for prompt gamma medical imaging [J].

Thirolf, P. G. ;

Aldawood, S. ;

Boehmer, M. ;

Bortfeldt, J. ;

Castelhano, I. ;

Dedes, G. ;

Fiedler, F. ;

Gernhaeuser, R. ;

Golnik, C. ;

Helmbrecht, S. ;

Hueso-Gonzalez, F. ;

Kolff, H. V. D. ;

Kormoll, T. ;

Lang, C. ;

Liprandi, S. ;

Lutter, R. ;

Marinsek, T. ;

Maier, L. ;

Pausch, G. ;

Petzoldt, J. ;

Roemer, K. ;

Schaart, D. ;

Parodi, K. .

12TH INTERNATIONAL CONFERENCE ON NUCLEUS-NUCLEUS COLLISIONS 2015, 2016, 117

[26] Development of a Compton Camera for Online Range Monitoring of Laser-Accelerated Proton Beams via Prompt-Gamma Detection [J].

Thirolf, P. G. ;

Lang, C. ;

Aldawood, S. ;

v.d. Kolff, H. G. ;

Maier, L. ;

Schaart, D. R. ;

Parodi, K. .

INPC 2013 - INTERNATIONAL NUCLEAR PHYSICS CONFERENCE, VOL. 2, 2014, 66

[27] Improved Nearest Neighbor Methods for Gamma Photon Interaction Position Determination in Monolithic Scintillator PET Detectors [J].

van Dam, Herman T. ;

Seifert, Stefan ;

Vinke, Ruud ;

Dendooven, Peter ;

Lohner, Herbert ;

Beekman, Freek J. ;

Schaart, Dennis R. .

IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2011, 58 (05) :2139-2147

[28] Optical simulation of monolithic scintillator detectors using GATE/GEANT4 [J].

van der Laan, D. J. ;

Schaart, Dennis R. ;

Maas, Marnix C. ;

Beekman, Freek J. ;

Bruyndonckx, Peter ;

van Eijk, Carel W. E. .

PHYSICS IN MEDICINE AND BIOLOGY, 2010, 55 (06) :1659-1675

[29]

[No title captured]

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