Development of a Compton camera for prompt-gamma medical imaging

被引：42

作者：

Aldawood, S. ^{[1
,2
]}

Thirolf, P. G. ^{[1
]}

Miani, A. ^{[1
,3
]}

Boehmer, M. ^{[4
]}

Dedes, G. ^{[1
]}

Gernhauser, R. ^{[4
]}

Lang, C. ^{[1
]}

Liprandi, S. ^{[1
]}

Maier, L. ^{[4
]}

Marinsek, T. ^{[1
]}

Mayerhofer, M. ^{[1
]}

Schaart, D. R. ^{[5
]}

Lozano, I. Valencia ^{[1
]}

Parodi, K. ^{[1
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Dept Med Phys, Fak Phys, Coulombwall 1, Garching, Germany

[2] King Saud Univ, Dept Phys & Astron, Riyadh, Saudi Arabia

[3] Univ Milan, Milan, Italy

[4] Tech Univ Munich, Garching, Germany

[5] Delft Univ Technol, Delft, Netherlands

来源：

RADIATION PHYSICS AND CHEMISTRY | 2017年 / 140卷

关键词：

Compton camera; Prompt-gamma imaging; Hadron therapy; Scintillation detectors; RANGE VERIFICATION; PET DETECTORS; PROTON-BEAMS; THERAPY; SIMULATION;

D O I：

10.1016/j.radphyschem.2017.01.024

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A Compton camera-based detector system for photon detection from nuclear reactions induced by proton (or heavier ion) beams is under development at LMU Munich, targeting the online range verification of the particle beam in hadron therapy via prompt-gamma imaging. The detector is designed to be capable to reconstruct the photon source origin not only from the Compton scattering kinematics of the primary photon, but also to allow for tracking of the secondary Compton-scattered electrons, thus enabling a gamma-source reconstruction also from incompletely absorbed photon events. The Compton camera consists of a monolithic LaBr3:Ce scintillation crystal, read out by a multi-anode PMT acting as absorber, preceded by a stacked array of 6 double-sided silicon strip detectors as scatterers. The detector components have been characterized both under offline and online conditions. The LaBr3:Ce crystal exhibits an excellent time and energy resolution. Using intense collimated Cs-137 and Co-60 sources, the monolithic scintillator was scanned on a fine 2D grid to generate a reference library of light amplitude distributions that allows for reconstructing the photon interaction position using a k-Nearest Neighbour (k-NN) algorithm. Systematic studies were performed to investigate the performance of the reconstruction algorithm, revealing an improvement of the spatial resolution with increasing photon energy to an optimum value of 3.7(1)mm at 1.33 MeV, achieved with the Categorical Average Pattern (CAP) modification of the k-NN algorithm.

引用

页码：190 / 197

页数：8

共 29 条

[1] Comparative Characterization Study of a LaBr3(Ce) Scintillation Crystal in Two Surface Wrapping Scenarios: Absorptive and Reflective [J].

Aldawood, Saad ;

Castelhano, Ines ;

Gemhaeuser, Roman ;

Van der Kolff, Hugh ;

Lang, Christian ;

Liprandi, Silvia ;

Lutter, Rudolf ;

Maier, Ludwig ;

Marinsek, Wm ;

Schaart, Dennis R. ;

Parodi, Katia ;

Thirolf, Peter G. .

FRONTIERS IN ONCOLOGY, 2015, 5

[2] Ionoacoustic characterization of the proton Bragg peak with submillimeter accuracy [J].

Assmann, W. ;

Kellnberger, S. ;

Reinhardt, S. ;

Lehrack, S. ;

Edlich, A. ;

Thirolf, P. G. ;

Moser, M. ;

Dollinger, G. ;

Omar, M. ;

Ntziachristos, V. ;

Parodi, K. .

MEDICAL PHYSICS, 2015, 42 (02) :567-574

[3] Range assessment in particle therapy based on prompt γ-ray timing measurements [J].

Golnik, Christian ;

Hueso-Gonzalez, Fernando ;

Muller, Andreas ;

Dendooven, Peter ;

Enghardt, Wolfgang ;

Fiedler, Fine ;

Kormoll, Thomas ;

Roemer, Katja ;

Petzoldt, Johannes ;

Wagner, Andreas ;

Pausch, Guntram .

PHYSICS IN MEDICINE AND BIOLOGY, 2014, 59 (18) :5399-5422

[4] Non-invasive monitoring of therapeutic carbon ion beams in a homogeneous phantom by tracking of secondary ions [J].

Gwosch, K. ;

Hartmann, B. ;

Jakubek, J. ;

Granja, C. ;

Soukup, P. ;

Jaekel, O. ;

Martisikova, M. .

PHYSICS IN MEDICINE AND BIOLOGY, 2013, 58 (11) :3755-3773

[5]

Hodges J.L., 1951, Tech. Rep. Project 21-49-004

[6] The GAMS4 flat crystal facility [J].

Kessler, EG ;

Dewey, MS ;

Deslattes, RD ;

Henins, A ;

Börner, HG ;

Jentschel, M ;

Lehmann, H .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2001, 457 (1-2) :187-202

[7] In vivo proton range verification: a review [J].

Knopf, Antje-Christin ;

Lomax, Antony .

PHYSICS IN MEDICINE AND BIOLOGY, 2013, 58 (15) :131-160

[8]

Kormoll T., 2012, NUCL INSTRUM METH A, V678, P626

[9]

Kormoll T., 2012, NUCL INSTRUM METH A, V11, P4

[10] Development of a Compton camera for medical applications based on silicon strip and scintillation detectors [J].

Krimmer, J. ;

Ley, J. -L. ;

Abellan, C. ;

Cachemiche, J. -P. ;

Caponetto, L. ;

Chen, X. ;

Dahoumane, M. ;

Dauvergne, D. ;

Freud, N. ;

Joly, B. ;

Lambert, D. ;

Lestand, L. ;

Letang, J. M. ;

Magne, M. ;

Mathez, H. ;

Maxim, V. ;

Montarou, G. ;

Morel, C. ;

Pinto, M. ;

Ray, C. ;

Reithinger, V. ;

Testa, E. ;

Zoccarato, Y. .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2015, 787 :98-101

← 1 2 3 →