Targeting the cell cycle in esophageal adenocarcinoma: An adjunct to anticancer treatment

被引:10
作者
Dibb, Martyn [1 ]
Ang, Yeng S. [1 ,2 ]
机构
[1] Royal Albert Edward Infirm, Dept Gastroenterol, Wigan WN1 2NN, Lancs, England
[2] Univ Manchester, Fac Med & Human Sci, Sch Translat Med, Manchester M13 9PL, Lancs, England
关键词
Esophageal adenocarcinoma; Cell cycle; Cyclin-dependent kinase; Aurora kinases; Polo-like kinase; POLO-LIKE KINASE; DNA-DAMAGE CHECKPOINT; BARRETTS-ESOPHAGUS; AURORA-B; SUBCELLULAR-LOCALIZATION; PROGNOSTIC-SIGNIFICANCE; NEOPLASTIC PROGRESSION; CANCER-PATIENTS; BREAST-CANCER; EXPRESSION;
D O I
10.3748/wjg.v17.i16.2063
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Esophageal adenocarcinoma is a major cause of cancer death in men in the developed world. Continuing poor outcomes with conventional therapies that predominantly target apoptosis pathways have lead to increasing interest in treatments that target the cell cycle. A large international effort has led to the development of a large number of inhibitors, which target cell cycle kinases, including cyclin-dependent kinases, Aurora kinases and polo-like kinase. Initial phase I / II trials in solid tumors have often demonstrated only modest clinical benefits of monotherapy. This may relate in part to a failure to identify the patient populations that will gain the most clinical benefit. Newer compounds lacking the side effect profile of first-generation compounds may show utility as adjunctive treatments targeted to an individual's predicted response to treatment. (C) 2011 Baishideng. All rights reserved.
引用
收藏
页码:2063 / 2069
页数:7
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