Study of TLR3, TLR4, and TLR9 in prostate carcinomas and their association with biochemical recurrence

被引：112

作者：

Gonzalez-Reyes, Salome ^{[3
]}

Fernandez, Jesus M. ^{[4
]}

Gonzalez, Luis O. ^{[3
]}

Aguirre, Alina ^{[3
]}

Suarez, Aurelio ^{[2
]}

Gonzalez, Jose M. ^{[3
]}

Escaff, Safwan ^{[2
,3
]}

Vizoso, Francisco J. ^{[1
,3
]}

机构：

[1] Hosp Jove, Serv Cirugia Gen, Gijon 33920, Asturias, Spain

[2] Hosp Jove, Serv Urol, Gijon 33920, Asturias, Spain

[3] Hosp Jove, Unidad Invest, Gijon 33920, Asturias, Spain

[4] Hosp Univ Cent Asturias, Serv Urol, Oviedo, Spain

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2011年 / 60卷 / 02期

关键词：

Prostate carcinoma; Tissue array; Real time PCR; Prognosis; TLR; Tumor invasion; TOLL-LIKE RECEPTORS; CANCER-CELLS; IMMUNE SURVEILLANCE; EPITHELIAL-CELLS; BREAST-CANCER; TUMOR-GROWTH; INFLAMMATION; DISEASE; INFECTION; BACTERIAL;

D O I：

10.1007/s00262-010-0931-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Toll-like receptors (TLRs) have garnered an extraordinary amount of interest in cancer research due to their role in tumor progression. By activating the production of several biological factors, TLRs induce type I interferons and other cytokines, which drive an inflammatory response and activate the adaptive immune system. The aim of this study was to investigate the expression and clinical relevance of TLR3, 4, and 9 in prostate cancer. The expression levels of TLR3, TLR4, and TLR9 were analyzed on tumors from 133 patients with prostate cancer. The analyses were performed by immunohistochemistry on tissue arrays and real time-PCR. Cancerous cells showed high expression levels of TLRs compared with controls. Samples of carcinomas with recurrence exhibited a significant increase in the mRNA levels of TLR3, TLR4, and TLR9. In addition, the tumors that showed high TLR3 or TLR9 expression levels were significantly associated with higher probability of biochemical recurrence. TLR expression is associated with prostate cancer with recurrence and the role of TLR receptors in the biology of malignancy merits study. Therapeutic strategies to boost or block TLRs may be of interest.

引用

页码：217 / 226

页数：10

共 62 条

[1] Recognition of pathogen-associated molecular patterns by TLR family [J].

Akira, S ;

Hemmi, H .

IMMUNOLOGY LETTERS, 2003, 85 (02) :85-95

[2] Long-term hazard of progression after radical prostatectomy for clinically localized prostate cancer: Continued rise of biochemical failure after 5 years [J].

Amling, CL ;

Blute, ML ;

Bergstralh, EJ ;

Seay, TM ;

Slezak, J ;

Zincke, H .

JOURNAL OF UROLOGY, 2000, 164 (01) :101-105

[3] Smoldering and polarized inflammation in the initiation and promotion of malignant disease [J].

Balkwill, F ;

Charles, KA ;

Mantovani, A .

CANCER CELL, 2005, 7 (03) :211-217

[4] CANCER - A BIOLOGICAL APPROACH .1. THE PROCESSES OF CONTROL [J].

BURNET, M .

BRITISH MEDICAL JOURNAL, 1957, 1 (APR6) :779-786

[5] Toll-like Receptor 3-Mediated Suppression of TRAMP Prostate Cancer Shows the Critical Role of Type I Interferons in Tumor Immune Surveillance [J].

Chin, Arnold I. ;

Miyahira, Andrea K. ;

Covarrubias, Anthony ;

Teague, Juli ;

Guo, Beichu ;

Dempsey, Paul W. ;

Cheng, Genhong .

CANCER RESEARCH, 2010, 70 (07) :2595-2603

[6] An approach for understanding the inflammation and cancer relationship [J].

Costantini, S. ;

Capone, F. ;

Guerriero, E. ;

Castello, G. .

IMMUNOLOGY LETTERS, 2009, 126 (1-2) :91-92

[7] Paradoxical roles of the immune system during cancer development [J].

de Visser, KE ;

Eichten, A ;

Coussens, LM .

NATURE REVIEWS CANCER, 2006, 6 (01) :24-37

[8] TISSUE INHIBITOR OF METALLOPROTEINASES (TIMP, AKA EPA) - STRUCTURE, CONTROL OF EXPRESSION AND BIOLOGICAL FUNCTIONS [J].

DENHARDT, DT ;

FENG, B ;

EDWARDS, DR ;

COCUZZI, ET ;

MALYANKAR, UM .

PHARMACOLOGY & THERAPEUTICS, 1993, 59 (03) :329-341

[9] Toll-like receptor 9 agonists promote IL-8 and TGF-β1production via activation of nuclear factor κB in PC-3 cells [J].

Di, Jin-ming ;

Pang, Jun ;

Pu, Xiao-yong ;

Zhang, Yan ;

Liu, Xiao-peng ;

Fang, You-qiang ;

Ruan, Xing-xing ;

Gao, Xin .

CANCER GENETICS AND CYTOGENETICS, 2009, 192 (02) :60-67

[10] Human lung cancer cells express functionally active Toll-like receptor 9 [J].

Droemann, D ;

Albrecht, D ;

Gerdes, J ;

Ulmer, AJ ;

Branscheid, D ;

Vollmer, E ;

Dalhoff, K ;

Zabel, P ;

Goldmann, T .

RESPIRATORY RESEARCH, 2005, 6 (01)

← 1 2 3 4 5 6 7 →