TOLERANCE AND MINIMIZATION OF IMMUNOSUPPRESSIVE THERAPY AFTER LIVER TRANSPLANTATION

被引：0

作者：

Gerasimova, O. A. ^{[1
,2
]}

Borovik, V. V. ^{[1
]}

Marchenko, N., V ^{[1
]}

Tileubergenov, I. I. ^{[1
]}

机构：

[1] Granov Russian Sci Ctr Radiol & Surg Technol, St Petersburg, Russia

[2] St Petersburg State Univ, St Petersburg, Russia

来源：

VESTNIK TRANSPLANTOLOGII I ISKUSSTVENNYH ORGANOV | 2021年 / 23卷 / 03期

关键词：

apoptosis; immune tolerance; immunosuppression; mesenchymal stem cells; regulatory T cells; liver transplant; NK cells; REGULATORY T-CELLS; WITHDRAWAL; APOPTOSIS; RAPAMYCIN; SURVIVAL;

D O I：

10.15825/1995-1191-2021-3-162-170

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

In this review of current publications, we look at the molecular mechanisms of tolerance of the liver and its allografts in terms of minimization and possibilities of withdrawing immunosuppressive therapy, mainly in the long-term period after liver transplantation. Information about clinical trials with regulatory T cells (Tregs) for the purpose of tolerance induction is presented. Data from a new consensus study on individualization of immunosuppressive therapy regimens are presented. Options for possible withdrawal of immunosuppression both in the early and in the long term after liver transplantation (LT) are considered. We suggest a way to study the lymphoproliferative potential of a liver transplant recipient to be investigated, since not only rejection determines life expectancy, but also the degree of immunosuppression effect on bone marrow depending on patient age.

引用

页码：162 / 170

页数：9

共 26 条

[1] Differences in Long-Term Survival Among Liver Transplant Recipients and the General Population: A Population-Based Nordic Study [J].

Aberg, Fredrik ;

Gissler, Mika ;

Karlsen, Tom H. ;

Ericzon, Bo-Goran ;

Foss, Aksel ;

Rasmussen, Allan ;

Bennet, William ;

Olausson, Michael ;

Line, Pal-Dag ;

Nordin, Arno ;

Bergquist, Annika ;

Boberg, Kirsten Muri ;

Castedal, Maria ;

Pedersen, Christian Ross ;

Isoniemi, Helena .

HEPATOLOGY, 2015, 61 (02) :668-677

[2] Prospective Multicenter Clinical Trial of Immunosuppressive Drug Withdrawal in Stable Adult Liver Transplant Recipients [J].

Benitez, Carlos ;

Londono, Maria-Carlota ;

Miquel, Rosa ;

Manzia, Tommaso-Maria ;

Abraldes, Juan G. ;

Lozano, Juan-Jose ;

Martinez-Llordella, Marc ;

Lopez, Marta ;

Angelico, Roberta ;

Bohne, Felix ;

Sese, Pilar ;

Daoud, Frederic ;

Larcier, Patrick ;

Roelen, Dave L. ;

Claas, Frans ;

Whitehouse, Gavin ;

Lerut, Jan ;

Pirenne, Jacques ;

Rimola, Antoni ;

Tisone, Giuseppe ;

Sanchez-Fueyo, Alberto .

HEPATOLOGY, 2013, 58 (05) :1824-1835

[3] Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection [J].

Boardman, D. A. ;

Philippeos, C. ;

Fruhwirth, G. O. ;

Ibrahim, M. A. A. ;

Hannen, R. F. ;

Cooper, D. ;

Marelli-Berg, F. M. ;

Watt, F. M. ;

Lechler, R. I. ;

Maher, J. ;

Smyth, L. A. ;

Lombardi, G. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2017, 17 (04) :931-943

[4] INDUCTION OF IMMUNOLOGICAL TOLERANCE BY PORCINE LIVER ALLOGRAFTS [J].

CALNE, RY ;

SELLS, RA ;

PENA, JR ;

DAVIS, DR ;

MILLARD, PR ;

HERBERTSON, BM ;

BINNS, RM ;

DAVIES, DAL .

NATURE, 1969, 223 (5205) :472-+

[5] Apoptosis: The nexus of liver injury and fibrosis [J].

Canbay, A ;

Friedman, S ;

Gores, GJ .

HEPATOLOGY, 2004, 39 (02) :273-278

[6] Immunosuppressive regimens for adult liver transplant recipients in real-life practice: consensus recommendations from an Italian Working Group [J].

Cillo, Umberto ;

De Carlis, Luciano ;

Del Gaudio, Massimo ;

De Simone, Paolo ;

Fagiuoli, Stefano ;

Lupo, Francesco ;

Tisone, Giuseppe ;

Volpes, Riccardo .

HEPATOLOGY INTERNATIONAL, 2020, 14 (06) :930-943

[7] Modification of immunosuppressive therapy as risk factor for complications after liver transplantation [J].

de Simone, Paolo ;

Carrai, Paola ;

Coletti, Laura ;

Ghinolfi, Davide ;

Petruccelli, Stefania ;

Filipponi, Franco .

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2017, 31 (02) :199-209

[8] Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance [J].

Diehl, Linda ;

Schurich, Anna ;

Grochtmann, Regina ;

Hegenbarth, Silke ;

Chen, Lieping ;

Knolle, Percy A. .

HEPATOLOGY, 2008, 47 (01) :296-305

[9] Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes [J].

Joffre, Olivier ;

Santolaria, Thibault ;

Calise, Denis ;

Al Saati, Talal ;

Hudrisier, Denis ;

Romagnoli, Paola ;

van Meerwijk, Joost P. M. .

NATURE MEDICINE, 2008, 14 (01) :88-92

[10] Different Effects of FK506, Rapamycin, and Mycophenolate Mofetil on Glucose-Stimulated Insulin Release and Apoptosis in Human Islets [J].

Johnson, James D. ;

Ao, Ziliang ;

Ao, Peter ;

Li, Hong ;

Dai, Long-Jun ;

He, Zehua ;

Tee, May ;

Potter, Kathryn J. ;

Klimek, Agnieszka M. ;

Meloche, R. Mark ;

Thompson, David M. ;

Verchere, C. Bruce ;

Warnockt, Garth L. .

CELL TRANSPLANTATION, 2009, 18 (08) :833-845

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