Estrogen Receptors and Melanoma: A Review

被引：51
作者：
Dika, Emi [1 ]
Patrizi, Annalisa [1 ]
Lambertini, Martina [1 ]
Manuelpillai, Nicholas [1 ]
Fiorentino, Michelangelo [2 ]
Altimari, Annalisa [3 ]
Ferracin, Manuela [2 ]
Lauriola, Mattia [4 ]
Fabbri, Enrica [2 ]
Campione, Elena [5 ]
Veronesi, Giulia [1 ]
Scarfi, Federica [1 ]
机构：
[1] Univ Bologna, DIMES, Dept Expt Diagnost & Specialty Med, Dermatol Sect, I-40138 Bologna, Italy
[2] Univ Bologna, DIMES, Dept Expt Diagnost & Specialty Med, Pathol Unit, I-40138 Bologna, Italy
[3] SOrsola Malpighi Hosp, Lab Oncol Mol Pathol, I-40138 Bologna, Italy
[4] Univ Bologna, DIMES, Dept Expt Diagnost & Specialty Med, Histol Embryol & Appl Biol Unit, I-40138 Bologna, Italy
[5] Univ Roma Tor Vergata, Dept Syst Med, Div Dermatol, I-00133 Rome, Italy
来源：
CELLS | 2019年 / 8卷 / 11期
关键词：
melanoma; woman; estrogens; CUTANEOUS MALIGNANT-MELANOMA; ORAL-CONTRACEPTIVE USE; BREAST-CANCER; REPRODUCTIVE FACTORS; SEX-DIFFERENCES; POOLED ANALYSIS; EUROPEAN ORGANIZATION; HORMONAL FACTORS; GENE-EXPRESSION; MESSENGER-RNA;
D O I：
10.3390/cells8111463
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In the last three decades cutaneous melanoma has been widely investigated as a steroid hormone-sensitive cancer. Following this hypothesis, many epidemiological studies have investigated the relationship between estrogens and melanoma. No evidence to date has supported this association due to the great complexity of genetic, external and environmental factors underlying the development of this cancer. Molecular mechanisms through which estrogen and their receptor exert a role in melanoma genesis are still under investigation with new studies increasingly focusing on the discovery of new molecular targets for therapeutic treatments.
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页数：13
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