Antiplatelet Agents in Acute ST Elevation Myocardial Infarction

被引：1

作者：

Kumar, Kris ^{[1
]}

Golwala, Harsh ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Portland, OR 97239 USA

来源：

AMERICAN JOURNAL OF MEDICINE | 2022年 / 135卷 / 06期

关键词：

Acute coronary syndrome; Antiplatelet; STEMI; PERCUTANEOUS CORONARY INTERVENTION; GLYCOPROTEIN IIB/IIIA INHIBITORS; TRIALS COMPARING INTRACORONARY; LOW-DOSE ASPIRIN; PLATELET INHIBITION; DOUBLE-BLIND; RECEPTOR ANTAGONIST; PREHOSPITAL INITIATION; PRIMARY ANGIOPLASTY; ABCIXIMAB;

D O I：

10.1016/j.amjmed.2022.01.042

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelet aggregation and thrombus formation represent the basic mechanism for clinical, electrocardiographic, and biomarker changes consistent with acute coronary syndrome. Various oral and intravenous formulations of platelet function inhibitors have been developed to help decrease platelet aggregation due to acute atherosclerotic plaque rupture. In this article, we review the various mechanisms, pharmacokinetics/pharmacodynamics, and the key clinical trials related to the platelet inhibitors that form the basis for current recommendations of their use in the ST elevation myocardial infarction guidelines by the American College of Cardiology/American Heart Association. (C) 2022 Elsevier Inc. All rights reserved.

引用

页码：697 / 708

页数：12

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