Anticancer Activities of an Anthocyanin-Rich Extract From Black Rice Against Breast Cancer Cells In Vitro and In Vivo

被引:174
作者
Chang Hui
Yu Bin
Yu Xiaoping
Yi Long
Chen Chunye
Mi Mantian [1 ]
Ling Wenhua [2 ]
机构
[1] Third Mil Univ, Res Ctr Nutr & Food Safety, Chongqing Key Lab Nutr & Food Safety, Chongqing 400038, Peoples R China
[2] Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou 510275, Guangdong, Peoples R China
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2010年 / 62卷 / 08期
基金
中国国家自然科学基金;
关键词
ATHEROSCLEROTIC PLAQUE-FORMATION; MICROVESSEL DENSITY; ANTIOXIDANT; APOPTOSIS; SUPPLEMENTATION; CARCINOMA; FRACTION; PROLIFERATION; SUPPRESSION; MECHANISMS;
D O I
10.1080/01635581.2010.494821
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Anthocyanins widely present in human diet and have a variety of health effects. This study investigates the anticancer effects of an anthocyanin-rich extract from black rice (AEBR) on breast cancer cells in vitro and in vivo. AEBR reduced the viability of breast cancer cell lines MCF-7 (ER+, HER2/neu-), MDA-MB-231 (ER-, HER2/neu-), and MDA-MB-453 (ER-, HER2/neu+) and induced apoptosis in MDA-MB-453 cells via the intrinsic pathway in vitro by activating caspase cascade, cleaving poly (ADP-ribose) polymerase (PARP), depolarizing mitochondrial membrane potential, and releasing cytochrome C. Oral administration of AEBR (100 mg/kg/day) to BALB/c nude mice bearing MDA-MB-453 cell xenografts significantly suppressed tumor growth and angiogenesis by suppressing the expression of angiogenesis factors MMP-9, MMP-2, and uPA in tumor tissue. Altogether, this study suggests the anticancer effects of AEBR against human breast cancer cells in vitro and in vivo by inducing apoptosis and suppressing angiogenesis.
引用
收藏
页码:1128 / 1136
页数:9
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