O-ethyl 1-azidoalkylphosphonic acids -: versatile reagents for the synthesis of protected phosphonamidate peptides

被引：16

作者：

Sikora, D ^{[1
]}

Nonas, T ^{[1
]}

Gajda, T ^{[1
]}

机构：

[1] Lodz Tech Univ, Inst Organ Chem, PL-90924 Lodz, Poland

来源：

TETRAHEDRON | 2001年 / 57卷 / 08期

关键词：

phosphonopeptides; phosphonamidates; diethyl; 1-azidoalkyl-phosphonates; amino acids; O-ethyl 1-azidoalkylphosphonic acids;

D O I：

10.1016/S0040-4020(00)01143-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new methodology for the synthesis of protected phosphonamidate peptides from O-ethyl 1-azidoalkylphosphonic acids and amino acids esters was developed. The method is general and the corresponding N-Boc protected phosphonopeptides as well as their azido analogs have been obtained in good yields. An efficient preparation of O-ethyl 1-azidoalkylphosphonic acids is also presented. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1619 / 1625

页数：7

共 38 条

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