CHARACTERIZATION OF A GROUP OF 12 PATIENTS WITH MEVALONATE KINASE DEFICIENCY: SYMPTOMS AND TREATMENT WITH IL-1 INHIBITORS

被引:0
|
作者
Kozlova, A. [1 ]
Burlakov, V. [1 ]
Kuzmenko, N. [1 ]
Zimin, S. [2 ]
Varlamova, T. [1 ]
Barabanova, O. [2 ]
Raikina, E. [1 ]
Shcherbina, A. [1 ]
机构
[1] Fed State Budgetary Inst, Natl Sci & Pract Ctr Pediat Hematol Oncol & Immun, Immunol, Moscow, Russia
[2] Childrens Clin Hosp 9, Immunol, Moscow, Russia
关键词
D O I
10.1136/annrheumdis-2017-eular.2238
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
THU0547
引用
收藏
页码:413 / 413
页数:1
相关论文
共 50 条
  • [1] CHARACTERIZATION OF A GROUP OF 6 PATIENTS WITH MEVALONATE KINASE DEFICIENCY: SYMPTOMS AND TREATMENT WITH IL-1 INHIBITORS
    Kozlova, A.
    Kuzmenko, N.
    Zimin, S.
    Varlamova, T.
    Shcherbina, A.
    ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 : 395 - 395
  • [2] Unprenylated RhoA Contributes to IL-1β Hypersecretion in Mevalonate Kinase Deficiency Model through Stimulation of Rac1 Activity
    van der Burgh, Robert
    Pervolaraki, Kalliopi
    Turkenburg, Marjolein
    Waterham, Hans R.
    Frenkel, Joost
    Boes, Marianne
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (40) : 27757 - 27765
  • [3] Successful treatment of refractory mevalonate kinase deficiency with combination therapy targeting TNFα and IL1β
    Martin, Celeste
    Scheers, Isabelle
    Triaille, Clement
    Boulanger, Cecile
    RHEUMATOLOGY, 2024, 63 (09) : e270 - e272
  • [4] Efficacy of Anakinra Treatment in two Moroccan Patients With Mevalonate Kinase Deficiency
    Souali, Manal
    Sakhi, Asmaa
    Bousfiha, Ahmed Aziz
    Bouayed, Kenza
    GLOBAL PEDIATRIC HEALTH, 2023, 10
  • [5] Treatment of rheumatoid arthritis with IL-1 inhibitors
    Gabay, C
    Arend, WP
    SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 1998, 20 (1-2): : 229 - 246
  • [6] Treatment of rheumatoid arthritis with IL-1 inhibitors
    Cem Gabay
    William P. Arend
    Springer Seminars in Immunopathology, 1998, 20 : 229 - 246
  • [7] Specific increase in caspase-1 activity and secretion of IL-1 family cytokines: a putative link between mevalonate kinase deficiency and inflammation
    Normand, Sylvain
    Massonnet, Benoit
    Delwail, Adriana
    Favot, Laure
    Cuisset, Laurence
    Grateau, Gilles
    Morel, Franck
    Silvain, Christine
    Lecron, Jean-Claude
    EUROPEAN CYTOKINE NETWORK, 2009, 20 (03) : 101 - 107
  • [8] Pharmacological inhibitors of the mevalonate pathway activate pro-IL-1 processing and IL-1 release by human monocytes
    Massonnet, Benoit
    Normand, Sylvain
    Moschitz, Reinhard
    Delwail, Adriana
    Favot, Laure
    Garcia, Martine
    Bourmeyster, Nicolas
    Cuisset, Laurence
    Grateau, Gilles
    Morel, Franck
    Silvain, Christine
    Lecron, Jean-Claude
    EUROPEAN CYTOKINE NETWORK, 2009, 20 (03) : 112 - 120
  • [9] IL-1 inhibitors: novel agents in the treatment of rheumatoid arthritis
    Gabay, C
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2000, 9 (01) : 113 - 127
  • [10] Influence of Circulating Tumour Cells on Production of IL-1α, IL-1β and IL-12 in Sera of Patients with Primary Diagnosis of Breast Cancer Before Treatment
    Vilsmaier, Theresa
    Rack, Brigitte
    Koenig, Alexander
    Friese, Klaus
    Janni, Wolfgang
    Jeschke, Udo
    Weissenbacher, Tobias
    ANTICANCER RESEARCH, 2016, 36 (10) : 5227 - 5236