The effect of orexin-A on the pathological mechanism in the rat focal cerebral ischemia

被引：53

作者：

Kitamura, Eiji ^{[1
]}

Hamada, Junichi ^{[1
]}

Kanazawa, Naomi ^{[1
]}

Yonekura, Junko ^{[1
]}

Masuda, Ray ^{[1
]}

Sakai, Fumihiko

Mochizuki, Hideki ^{[1
]}

机构：

[1] Kitasato Univ Sch Med, Dept Neurol, Minami Ku, Kanagawa 2520374, Japan

来源：

NEUROSCIENCE RESEARCH | 2010年 / 68卷 / 02期

关键词：

Orexin-A; Middle cerebral artery occlusion (MCAO); Brain ischemia; Neuroprotective effect; Rats; 2,3,5-Triphenyltetrazolium chloride (TTC); ARTERY OCCLUSION; RECEPTOR; NEURONS; ADULT;

D O I：

10.1016/j.neures.2010.06.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Orexin-A is a neuropeptide involved in the control feeding, arousal or sleep behavior in the hypothalamus. In the present study, the cortex and lateral hypothalamus of rats subjected to middle cerebral artery occlusion (MCAO)-reperfusion brain injury were examined by double immunofluorescence staining. The number of orexin-A-expressing neurons in the non-ischemic side was significantly lower than the ischemic side. Next, orexin-A was administered intracerebroventricularly followed by the induction of MCAO-reperfusion injury. Administration of orexin-A at 0.3 nmol significantly reduced the brain infarct area. The results suggested that orexin-A alters the pathological mechanisms involved in brain ischemia and has a neuroprotective effect. (C) 2010 Elsevier Ireland Ltd and the japan Neuroscience Society. All rights reserved.

引用

页码：154 / 157

页数：4

共 50 条

[41] Effect of propofol pretreatment on apoptosis in rat brain cortex after focal cerebral ischemia and reperfusion [J].

Xu, Haiyan ;

Zhang, Chengwei ;

Zhang, Chunxiao .

NEURAL REGENERATION RESEARCH, 2011, 6 (14) :1086-1090

[42] Effects of Pretreatment with a Combination of Melatonin and Electroacupuncture in a Rat Model of Transient Focal Cerebral Ischemia [J].

Liu, Lingguang ;

Cheung, R. T. F. .

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2013, 2013

[43] Acute cerebral ischaemia: Relationship between serum and cerebrospinal fluid orexin-A concentration and infarct volume [J].

Kotan, Dilcan ;

Deniz, Orhan ;

Aygul, Recep ;

Yildirim, Abdulkadir .

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2013, 41 (02) :404-409

[44] Administration of Orexin-A into the Rat Thalamic Paraventricular Nucleus Enhances the Naloxone Induced Morphine Withdrawal [J].

Babaie, Fatemeh ;

Kourosh-Arami, Masoumeh ;

Farhadi, Mona .

DRUG RESEARCH, 2022, 72 (04) :209-214

[45] Involvement of orexin-A on micturition reflex in normal and cyclophosphamide-induced cystitis bladder in rat [J].

Kobayashi, Mizuki ;

Nomura, Masayoshi ;

Fujihara, Hiroaki ;

Suzuki, Hitoshi ;

Otsubo, Hiroki ;

Nishii, Hisae ;

Fujimoto, Naohiro ;

Matsumoto, Tetsuro ;

Ueta, Yoichi .

PEPTIDES, 2009, 30 (12) :2348-2356

[46] The Neuroprotective Effect of Glycyrrhizic Acid on an Experimental Model of Focal Cerebral Ischemia in Rats [J].

Akman, Tarik ;

Guven, Mustafa ;

Aras, Adem Bozkurt ;

Ozkan, Adile ;

Sen, Halil Murat ;

Okuyucu, Ali ;

Kalkan, Yildiray ;

Sehitoglu, Ibrahim ;

Silan, Coskun ;

Cosar, Murat .

INFLAMMATION, 2015, 38 (04) :1581-1588

[47] The Intrinsic PEDF is Regulated by PPARγ in Permanent Focal Cerebral Ischemia of Rat [J].

Zhu, Chunhua ;

Zhang, Xiangjian ;

Qiao, Huimin ;

Wang, Lina ;

Zhang, Xiaolin ;

Xing, Yinxue ;

Wang, Chaohui ;

Dong, Lipeng ;

Ji, Ye ;

Cao, Xiaoyun .

NEUROCHEMICAL RESEARCH, 2012, 37 (10) :2099-2107

[48] Selenoprotein S expression in the rat brain following focal cerebral ischemia [J].

Liu, Li Xia ;

Zhou, Xue Ying ;

Li, Cheng Shan ;

Liu, Li Qing ;

Huang, Shan Ying ;

Zhou, Sheng Nian .

NEUROLOGICAL SCIENCES, 2013, 34 (09) :1671-1678

[49] Changes in Gene Expression in the Rat Hippocampus after Focal Cerebral Ischemia [J].

Chung, Jun Young ;

Yi, Jae Woo ;

Kim, Sung Min ;

Lim, Young Jin ;

Chung, Joo Ho ;

Jo, Dae Jean .

JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, 2011, 50 (03) :173-178

[50] Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia [J].

Kim, Yu Ri ;

Kim, Ha Neui ;

Jang, Ji Yeon ;

Park, Cheol ;

Lee, Jun Hyuk ;

Shin, Hwa Kyoung ;

Choi, Yung Hyun ;

Choi, Byung Tae .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2013, 32 (06) :1303-1310

← 1 2 3 4 5 →