The effect of orexin-A on the pathological mechanism in the rat focal cerebral ischemia

被引：53
作者：
Kitamura, Eiji [1 ]
Hamada, Junichi [1 ]
Kanazawa, Naomi [1 ]
Yonekura, Junko [1 ]
Masuda, Ray [1 ]
Sakai, Fumihiko
Mochizuki, Hideki [1 ]
机构：
[1] Kitasato Univ Sch Med, Dept Neurol, Minami Ku, Kanagawa 2520374, Japan
来源：
NEUROSCIENCE RESEARCH | 2010年 / 68卷 / 02期
关键词：
Orexin-A; Middle cerebral artery occlusion (MCAO); Brain ischemia; Neuroprotective effect; Rats; 2,3,5-Triphenyltetrazolium chloride (TTC); ARTERY OCCLUSION; RECEPTOR; NEURONS; ADULT;
D O I：
10.1016/j.neures.2010.06.010
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Orexin-A is a neuropeptide involved in the control feeding, arousal or sleep behavior in the hypothalamus. In the present study, the cortex and lateral hypothalamus of rats subjected to middle cerebral artery occlusion (MCAO)-reperfusion brain injury were examined by double immunofluorescence staining. The number of orexin-A-expressing neurons in the non-ischemic side was significantly lower than the ischemic side. Next, orexin-A was administered intracerebroventricularly followed by the induction of MCAO-reperfusion injury. Administration of orexin-A at 0.3 nmol significantly reduced the brain infarct area. The results suggested that orexin-A alters the pathological mechanisms involved in brain ischemia and has a neuroprotective effect. (C) 2010 Elsevier Ireland Ltd and the japan Neuroscience Society. All rights reserved.
引用
收藏
页码：154 / 157
页数：4
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