Responses to serotonin (5HT) in isolated corpus cavernosum penis of rabbit

被引：10
作者：
Furukawa, K
Nagao, K
Ishii, N
Uchiyama, T
机构：
[1] Toho Univ, Fac Med, Dept Pharmacol, Ota Ku, Tokyo 1438540, Japan
[2] Toho Univ, Fac Med, Dept Urol, Ota Ku, Tokyo, Japan
来源：
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH | 2003年 / 15卷 / 04期
关键词：
serotonin; corpus cavernosum penis; contraction; 5HT(1A) receptor; 5HT(2) receptor; 5HT(4) receptor; rabbit;
D O I：
10.1038/sj.ijir.3901004
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
This study was aimed at determining serotonin (5-hydroxytryptamine: 5HT) receptor subtypes participating in 5HT-induced response in the isolated corpus cavernosum penis (CCP) of rabbits. 5HT contracted the CCP in a concentration-dependent manner. Both WAY100635 (5HT(1A) antagonist) and LY53857 (5HT(2) antagonist) concentration-dependently suppressed the 5HT-induced contraction. The suppression of the 5HT-induced contraction by ketanserin (5HT(2A) antagonist) was weaker than that by LY53857. LY278584 (5HT(3) antagonist) did not affect the 5HT-induced contraction. SDZ205557 (5HT(4) antagonist) showed a tendency to potentiate the 5HT-induced contraction. The above results suggest that 5HT(1A) and 5HT(2) receptor subtypes partially participate in the contractile response to 5HT in rabbit CCP, and the potentiation by SDZ205557 of the 5HT-induced contraction implies the existence of dual contractile and relaxing responses to 5HT via 5HT(1) and 5HT(2), and 5HT(4) receptors, respectively. The relaxing response to 5HT(4) receptor stimulation may be masked by 5HT-induced contraction.
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收藏
页码：267 / 271
页数：5
相关论文
共 21 条
[1]   DRUG-INDUCED PENILE ERECTIONS IN RATS - INDICATIONS OF SEROTONIN1B RECEPTOR MEDIATION [J].
BERENDSEN, HHG ;
BROEKKAMP, CLE .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 135 (03) :279-287
[2]   INVOLVEMENT OF 5-HT1C-RECEPTORS IN DRUG-INDUCED PENILE ERECTIONS IN RATS [J].
BERENDSEN, HHG ;
JENCK, F ;
BROEKKAMP, CLE .
PSYCHOPHARMACOLOGY, 1990, 101 (01) :57-61
[3]  
COHEN ML, 1983, J PHARMACOL EXP THER, V227, P327
[4]   THE ACTION OF SDZ 205,557 AT 5-HYDROXYTRYPTAMINE (5-HT3 AND 5-HT4) RECEPTORS [J].
EGLEN, RM ;
ALVAREZ, R ;
JOHNSON, LG ;
LEUNG, E ;
WONG, EHF .
BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 (02) :376-382
[5]   INDAZOLES AS INDOLE BIOISOSTERES - SYNTHESIS AND EVALUATION OF THE TROPANYL ESTER AND AMIDE OF INDAZOLE-3-CARBOXYLATE AS ANTAGONISTS AT THE SEROTONIN 5HT3 RECEPTOR [J].
FLUDZINSKI, P ;
EVRARD, DA ;
BLOOMQUIST, WE ;
LACEFIELD, WB ;
PFEIFER, W ;
JONES, ND ;
DEETER, JB ;
COHEN, ML .
JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (09) :1535-1537
[6]  
FOSTER EA, 1995, EUR J PHARMACOL, V281, P81
[7]   alpha(1B)-adrenoceptor subtype mediating the phenylephrine-induced contractile response in rabbit corpus cavernosum penis [J].
Furukawa, K ;
ChessWilliams, R ;
Uchiyama, T .
JAPANESE JOURNAL OF PHARMACOLOGY, 1996, 71 (04) :325-331
[8]   Functional characteristics of heterologously expressed 5-HT receptors [J].
Gerhardt, CC ;
vanHeerikhuizen, H .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 334 (01) :1-23
[9]  
Gessa G L, 1974, Adv Biochem Psychopharmacol, V11, P217
[10]   Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT2B receptors [J].
Glusa, E ;
Pertz, HH .
BRITISH JOURNAL OF PHARMACOLOGY, 2000, 130 (03) :692-698
123