Global stability of a diffusive and delayed virus dynamics model with Crowley-Martin incidence function and CTL immune response

被引:25
作者
Kang, Chengjun [1 ,2 ]
Miao, Hui [2 ]
Chen, Xing [1 ]
Xu, Jiabo [1 ]
Da Huang [1 ]
机构
[1] Xinjiang Inst Engn, Dept Math, Urumqi 830091, Xinjiang, Peoples R China
[2] Shanxi Univ Finance & Econ, Coll Appl Math, Taiyuan 030006, Shanxi, Peoples R China
来源
ADVANCES IN DIFFERENCE EQUATIONS | 2017年
关键词
virus infection model; diffusion; delay; Lyapunov functional; stability; 2 TIME DELAYS; FRACTIONAL-ORDER MODEL; VIRAL-INFECTION MODEL; INTRACELLULAR DELAY; HIV-INFECTION; HBV MODEL; PARABOLIC-SYSTEMS; POPULATION; EXISTENCE; EQUATIONS;
D O I
10.1186/s13662-017-1332-x
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
In this paper, a diffusive and delayed virus dynamics model with Crowley-Martin incidence function and CTL immune response is investigated. By constructing the Lyapunov functionals, the threshold conditions on the global stability of the infection-free, immune-free and interior equilibria are established if the space is assumed to be homogeneous. We show that the infection-free equilibrium is globally asymptotically stable if the basic reproductive number R-0 <= 1; the immune-free equilibrium is globally asymptotically stable if the immune reproduction number and the basic reproduction number satisfy R-1 <= 1 < R-0; the interior equilibrium is globally asymptotically stable if R-1 > 1.
引用
收藏
页数:16
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