Synthesis of chiral piperazin-2-ones through palladium-catalyzed asymmetric hydrogenation of pyrazin-2-ols

被引：9
作者：
Feng, Guang-Shou [1 ]
Zhao, Zi-Biao [1 ]
Shi, Lei [2 ]
Zhou, Yong-Gui [1 ,3 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
[2] Dalian Univ Technol, Sch Chem Engn, Dalian 116024, Peoples R China
[3] Dalian Univ Technol, Zhang Dayu Sch Chem, Dalian 116024, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 22期
基金：
中国国家自然科学基金;
关键词：
ENANTIOSELECTIVE SYNTHESIS; KINETIC RESOLUTION; PIPERAZINONE RINGS; TETRAHYDROPYRAZINES; PSEUDOTHEONAMIDES; 2-OXOPIPERAZINES; PYRAZINES;
D O I：
10.1039/d1qo01144h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed asymmetric hydrogenation of pyrazines containing a tautomeric hydroxyl group has been developed, providing a facile access to chiral disubstituted piperazin-2-ones with excellent diastereoselectivities and enantioselectivities. The product could be conveniently converted into chiral piperazines without loss of optical purity.
引用
收藏
页码：6273 / 6278
页数：6
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