Synthesis of chiral piperazin-2-ones through palladium-catalyzed asymmetric hydrogenation of pyrazin-2-ols

被引：9

作者：

Feng, Guang-Shou ^{[1
]}

Zhao, Zi-Biao ^{[1
]}

Shi, Lei ^{[2
]}

Zhou, Yong-Gui ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

[2] Dalian Univ Technol, Sch Chem Engn, Dalian 116024, Peoples R China

[3] Dalian Univ Technol, Zhang Dayu Sch Chem, Dalian 116024, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 22期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE SYNTHESIS; KINETIC RESOLUTION; PIPERAZINONE RINGS; TETRAHYDROPYRAZINES; PSEUDOTHEONAMIDES; 2-OXOPIPERAZINES; PYRAZINES;

D O I：

10.1039/d1qo01144h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed asymmetric hydrogenation of pyrazines containing a tautomeric hydroxyl group has been developed, providing a facile access to chiral disubstituted piperazin-2-ones with excellent diastereoselectivities and enantioselectivities. The product could be conveniently converted into chiral piperazines without loss of optical purity.

引用

页码：6273 / 6278

页数：6

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