The Roles of Acidosis in Osteoclast Biology

被引：56
作者：
Yuan, Feng-Lai [1 ,2 ]
Xu, Ming-Hui [1 ,2 ]
Li, Xia [1 ,2 ]
He Xinlong [1 ,2 ]
Fang, Wei [3 ]
Dong, Jian [4 ]
机构：
[1] Nantong Univ, Hosp 3, Dept Orthopaed, Wuxi, Peoples R China
[2] Nantong Univ, Hosp 3, Cent Lab, Wuxi, Peoples R China
[3] Soochow Univ, Wuxi Peoples Hosp 9, Dept Neurosurg, Liangxi Rd Wuxi, Suzhou, Peoples R China
[4] Fudan Univ, Zhongshan Hosp, Dept Orthoped Surg, Shanghai 200433, Peoples R China
来源：
FRONTIERS IN PHYSIOLOGY | 2016年 / 7卷
关键词：
acidosis; osteoclast; osteoclast activity; osteoclast survival; osteoclast adhesion; SENSING ION CHANNELS; NUCLEUS PULPOSUS CELLS; COUPLED RECEPTOR 1; MICE LACKING; EXTRACELLULAR ACIDIFICATION; METABOLIC-ACIDOSIS; BONE-RESORPTION; RAT OSTEOCLASTS; ARTICULAR CHONDROCYTES; INTRACELLULAR CALCIUM;
D O I：
10.3389/fphys.2016.00222
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The adverse effect of acidosis on the skeletal system has been recognized for almost a century. Although the underlying mechanism has not been fully elucidated, it appears that acidosis acts as a general stimulator of osteoclasts derived from bone marrow precursors cells and enhances osteoclastic resorption. Prior work suggests that acidosis plays a significant role in osteoclasts formation and activation via up-regulating various genes responsible for its adhesion, migration, survival and bone matrix degradation. Understanding the role of acidosis in osteoclast biology may lead to development of novel therapeutic approaches for the treatment of diseases related to low bone mass. In this review, we aim to discuss the recent investigations into the effects of acidosis in osteoclast biology and the acid-sensing molecular mechanism.
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页数：8
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