Androgen receptor variants in prostate cancer

被引：3
作者：
Schreyer, Edwige [1 ]
Barthelemy, Philippe [1 ,3 ]
Cottard, Felicie [2 ]
Madi-Berthelemy, Pauline Ould [1 ]
Schaff-Wendling, Frederique [1 ,3 ]
Kurtz, Jean-Emmanuel [1 ,3 ]
Ceraline, Jocelyn [1 ,3 ]
机构：
[1] Univ Strasbourg, INSERM, VSDSC UMR S 1113, IGBMC, 1 Rue Laurent Fries,BP 10142, F-67404 Illkirch Graffenstaden, France
[2] Univ Freiburg, Med Ctr, Ctr Clin Res, Dept Urol, Breisacherstr 66, Freiburg, Germany
[3] Hop Univ Strasbourg, Serv Oncol & Hematol, F-67000 Strasbourg, France
来源：
M S-MEDECINE SCIENCES | 2017年 / 33卷 / 8-9期
关键词：
SPLICE VARIANT; DEPRIVATION THERAPY; ADAPTIVE RESPONSES; TUMOR-CELLS; STEM-CELLS; PROGRESSION; EXPRESSION; RESISTANCE; AR-V7; GROWTH;
D O I：
10.1051/medsci/20173308021
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Prostate cancer is a public health concern as it currently represents the most frequent malignancy in men in Europe. Progression of this hormone-dependent cancer is driven by androgens. Thus, the most common treatment for patients with advanced prostate cancer consists in an androgen ablation by castration therapy. However, the majority of patients relapses and develops a castration-resistant prostate cancer. This failure of androgen deprivation is related to the emergence of mutant and splice variants of the androgen receptor. Indeed, androgen receptor variants are ligand-independent, constitutively active and thus able to induce resistance to castration. This review focuses on AR variants signaling pathways and their role in resistance to castration and prostate cancer progression.
引用
收藏
页码：758 / 764
页数：7
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