High Expression of MTA1 Predicts Unfavorable Survival in Patients With Oral Squamous Cell Carcinoma

被引：6
作者：
Lin, Kuan-Yu [1 ]
Su, Tzu-Cheng [2 ]
Yeh, Chung-Min [2 ,3 ]
Chao, Wan-Ru [1 ,4 ,5 ]
Sung, Wen-Wei [1 ,6 ,7 ]
机构：
[1] Chung Shan Med Univ, Sch Med, 110,Sect 1,Jianguo N Rd, Taichung 40201, Taiwan
[2] Changhua Christian Hosp, Dept Pathol, Changhua, Taiwan
[3] Jen Teh Jr Coll Med Nursing & Management, Dept Med Technol, Miaoli, Taiwan
[4] Chung Shan Med Univ, Dept Pathol, Taichung, Taiwan
[5] Chung Shan Med Univ Hosp, Dept Pathol, Taichung, Taiwan
[6] Chung Shan Med Univ, Inst Med, Taichung, Taiwan
[7] Chung Shan Med Univ Hosp, Dept Urol, Taichung, Taiwan
来源：
IN VIVO | 2021年 / 35卷 / 04期
关键词：
Metastasis-associated protein 1; MTA1; prognosis; oral squamous cell carcinoma; overall survival; MAMMARY ADENOCARCINOMA; NUCLEAR EXPRESSION; CANCER; METASTASIS; ESTROGEN; PROMOTES; PROGRESSION; COMPLEX; GENE; NURD;
D O I：
10.21873/invivo.12513
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background/Aim: Metastasis-associated protein 1 (MTA1) plays a role in ATP-dependent nucleosome disruption activity and histone deacetylase activity and may indicate DNA methylation activity. MTA1 may also be involved in the progression of oral squamous cell carcinoma (OSCC). Patients and Methods: MTA1 immunoreactivity was analyzed using immunohistochemical (IHC) staining analysis in specimens from 281 OSCC patients. Kaplan-Meier analysis was used to determine the prognostic value of MTA1 for overall survival. Results: High MTA1 expression was significantly associated with female gender and lymph node metastasis. Multivariate analyses showed the independent prognostic role of high MTA1 expression in patients with OSCC of poorer mean survival. Conclusion: MTA1 expression, detected by IHC staining, could be an independent prognostic marker for patients of OSCC.
引用
收藏
页码：2363 / 2368
页数：6
相关论文
共 39 条
[11]   Hallmarks of Cancer: The Next Generation [J].
Hanahan, Douglas ;
Weinberg, Robert A. .
CELL, 2011, 144 (05) :646-674
[12]   The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma [J].
Hwang, Jau-Chung ;
Sung, Wen-Wei ;
Tu, Hung-Pin ;
Hsieh, Kun-Chou ;
Yeh, Chung-Min ;
Chen, Chih-Jung ;
Tai, Hui-Chun ;
Hsu, Chao-Tien ;
Shieh, Grace S. ;
Chang, Jan-Gowth ;
Yeh, Kun-Tu ;
Liu, Ta-Chih .
PLOS ONE, 2015, 10 (10)
[13]   Overexpression of metastasis-associated MTA1 in oral squamous cell carcinomas: correlation with metastasis and invasion [J].
Kawasaki, G. ;
Yanamoto, S. ;
Yoshitomi, I. ;
Yamada, S. ;
Mizuno, A. .
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2008, 37 (11) :1039-1046
[14]   Molecular mechanisms of epithelial-mesenchymal transition [J].
Lamouille, Samy ;
Xu, Jian ;
Derynck, Rik .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (03) :178-196
[15]   Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study [J].
Lee, Yi-Ju ;
Chan, Lung ;
Yeh, Chung-Min ;
Lee, Chien-Hsun ;
Sung, Wen-Wei .
MEDICINA-LITHUANIA, 2020, 56 (02)
[16]   A TGF-β-MTA1-SOX4-EZH2 signaling axis drives epithelial-mesenchymal transition in tumor metastasis [J].
Li, Lina ;
Liu, Jian ;
Xue, Hongsheng ;
Li, Chunxiao ;
Liu, Qun ;
Zhou, Yantong ;
Wang, Ting ;
Wang, Haijuan ;
Qian, Haili ;
Wen, Tao .
ONCOGENE, 2020, 39 (10) :2125-2139
[17]   Critical evaluation of diagnostic aids for the detection of oral cancer [J].
Lingen, Mark W. ;
Kalmar, John R. ;
Karrison, Theodore ;
Speight, Paul M. .
ORAL ONCOLOGY, 2008, 44 (01) :10-22
[18]   Estrogen receptor alpha regulates the Wnt/β-catenin signaling pathway in colon cancer by targeting the NOD-like receptors [J].
Liu, Shuhui ;
Fan, Wentao ;
Gao, Xiaona ;
Huang, Kehe ;
Ding, Chenchen ;
Ma, Guangpeng ;
Yan, Liping ;
Song, Suquan .
CELLULAR SIGNALLING, 2019, 61 :86-92
[19]   Metastasis-associated protein 1 (MTA1) in gastric cancer tissues is positively associated with poorer prognosis [J].
Lv, Zhen-ye ;
Zhao, Zhong-Sheng ;
Ye, Zai-Yuan ;
Wang, Yuan-Yu ;
Wang, Hui-Ju ;
Yang, Qiong .
PATHOLOGY RESEARCH AND PRACTICE, 2018, 214 (04) :536-541
[20]   MTA1 expression in human cancers - Clinical and pharmacological significance [J].
Malisetty, Vijaya Lakshmi ;
Penugurti, Vasudevarao ;
Panta, Prashanth ;
Chitta, Suresh Kumar ;
Manavathi, Bramanandam .
BIOMEDICINE & PHARMACOTHERAPY, 2017, 95 :956-964
1234