Adaptive inducibility of CREM as transcriptional memory of circadian rhythms

被引：86

作者：

Foulkes, NS ^{[1
]}

Duval, G ^{[1
]}

SassoneCorsi, P ^{[1
]}

机构：

[1] INST GENET & BIOL MOL & CELLULAIRE,F-67404 ILLKIRCH GRAFFENS,FRANCE

来源：

NATURE | 1996年 / 381卷 / 6577期

关键词：

D O I：

10.1038/381083a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

THE CREM gene(1-4) encodes the transcriptional repressor ICER(3,5), which has been implicated in the molecular mechanisms controlling circadian rhythms in mammals(4-6). ICER is rhythmically expressed in the pineal gland, with peak levels occurring at night(5). ICER levels are regulated by light by means of the suprachiasmatic nucleus (SCN); transcription is induced during darkness by adrenergic input to the pineal gland from the SCN, which activates the ICER promoter using cyclic AMP and the transcriptional activator CREB. This induction is transient because ICER represses its own transcription(3), Here we show that the response of the CREM gene to adrenergic stimulation is determined by night length, Depending on the photoperiod of the prior entraining cycles, the CREM gene is either subsensitive or supersensitive to induction. This differential responsiveness is controlled by the changing balance between positive (CREB) and negative (ICER) transcriptional regulators. Thus, the transcriptional response of the CREM gene is determined by the memory of past photoperiods.

引用

页码：83 / 85

页数：3

共 30 条

[11] REGULATION OF CREB PHOSPHORYLATION IN THE SUPRACHIASMATIC NUCLEUS BY LIGHT AND A CIRCADIAN CLOCK [J].

GINTY, DD ;

KORNHAUSER, JM ;

THOMPSON, MA ;

BADING, H ;

MAYO, KE ;

TAKAHASHI, JS ;

GREENBERG, ME .

SCIENCE, 1993, 260 (5105) :238-241

[12] CAMP CONTRIBUTES TO MESSY FIBER LTP BY INITIATING BOTH A COVALENTLY MEDIATED EARLY PHASE AND MACROMOLECULAR SYNTHESIS-DEPENDENT LATE-PHASE [J].

HUANG, YY ;

LI, XC ;

KANDEL, ER .

CELL, 1994, 79 (01) :69-79

[13] ENTRAINMENT OF THE CIRCADIAN-RHYTHM IN RAT PINEAL N-ACETYLTRANSFERASE ACTIVITY UNDER EXTREMELY LONG AND SHORT PHOTOPERIODS [J].

ILLNEROVA, H ;

VANECEK, J .

JOURNAL OF PINEAL RESEARCH, 1985, 2 (01) :67-78

[14]

Illnerova H, 1988, Pineal Res Rev, V6, P173

[15]

ILNEROVA H, 1986, CIRCADIAN RHYTHMS MA, P1

[16] THYROID-STIMULATING HORMONE (TSH)-DIRECTED INDUCTION OF THE CREM GENE IN THE THYROID-GLAND PARTICIPATES IN THE LONG-TERM DESENSITIZATION OF THE TSH RECEPTOR [J].

LALLI, E ;

SASSONECORSI, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (21) :9633-9637

[17] INDUCIBILITY AND NEGATIVE AUTOREGULATION OF CREM - AN ALTERNATIVE PROMOTER DIRECTS THE EXPRESSION OF ICER, AN EARLY RESPONSE REPRESSOR [J].

MOLINA, CA ;

FOULKES, NS ;

LALLI, E ;

SASSONECORSI, P .

CELL, 1993, 75 (05) :875-886

[18] PITUITARY FOLLICLE-STIMULATING-HORMONE (FSH) INDUCES CREM GENE-EXPRESSION IN SERTOLI CELLS - INVOLVEMENT IN LONG-TERM DESENSITIZATION OF THE FSH RECEPTOR [J].

MONACO, L ;

FOULKES, NS ;

SASSONECORSI, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (23) :10673-10677

[19] PINEAL MELATONIN - CELL BIOLOGY OF ITS SYNTHESIS AND OF ITS PHYSIOLOGICAL INTERACTIONS [J].

REITER, RJ .

ENDOCRINE REVIEWS, 1991, 12 (02) :151-180

[20] BETA-ADRENERGIC STIMULATION OF PINEAL N-ACETYLTRANSFERASE - ADENOSINE 3'-5'-CYCLIC MONOPHOSPHATE STIMULATES BOTH RNA AND PROTEIN-SYNTHESIS [J].

ROMERO, JA ;

ZATZ, M ;

AXELROD, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (06) :2107-2111

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