Charcot-Leyden crystals and other protein crystals driving type 2 immunity and allergy

被引：31

作者：

Aegerter, Helena ^{[1
,2
]}

Smole, Ursula ^{[1
,2
]}

Heyndrickx, Ines ^{[1
,2
]}

Verstraete, Kenneth ^{[3
,4
]}

Savvides, Savvas N. ^{[3
,4
]}

Hammad, Hamida ^{[1
,2
]}

Lambrecht, Bart N. ^{[1
,2
,5
]}

机构：

[1] VIB Ctr Inflammat Res, Immunoregulat Unit, Ghent, Belgium

[2] Univ Ghent, Dept Internal Med & Pediat, Ghent, Belgium

[3] VIB Ctr Inflammat Res, Unit Struct Biol, Ghent, Belgium

[4] Univ Ghent, Dept Biochem & Microbiol, Ghent, Belgium

[5] ErasmusMC, Dept Pulm Med, Rotterdam, Netherlands

来源：

CURRENT OPINION IN IMMUNOLOGY | 2021年 / 72卷

关键词：

CHITINASE-LIKE PROTEINS; LAVAGE FLUID PROTEOME; BIOCHEMICAL-CHARACTERIZATION; YM1; EXPRESSION; IDENTIFICATION; INFLAMMATION; LECTIN; CRYSTALLIZATION; RHINOSINUSITIS;

D O I：

10.1016/j.coi.2021.03.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Protein crystals derived from innate immune cells have been synonymous with a Type-2 immune response in both mouse and man for over 150 years. Eosinophilic Galectin-10 (Charcot-Leyden) crystals in humans, and Ym1/Ym2 crystals in mice are frequently found in the context of parasitic infections, but also in diseases such as asthma and chronic rhinosinusitis. Despite their notable presence, these crystals are often overlooked as trivial markers of Type-2 inflammation. Here, we discuss the source, context, and role of protein crystallization. We focus on similarities observed between Galectin-10 and Ym1/2 crystals in driving immune responses; the subsequent benefit to the host during worm infection, and conversely the detrimental exacerbation of inflammation and mucus production during asthma.

引用

页码：104 / 110

页数：7

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