Recent findings from the human proteome project: opening the mass spectrometry toolbox to advance cancer diagnosis, surveillance and treatment

被引：11

作者：

Cantor, David I. ^{[1
]}

Nice, Edouard C. ^{[2
]}

Baker, Mark S. ^{[1
]}

机构：

[1] Macquarie Univ, Fac Med & Hlth Sci, Australian Sch Adv Med, N Ryde, NSW 2109, Australia

[2] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia

来源：

EXPERT REVIEW OF PROTEOMICS | 2015年 / 12卷 / 03期

关键词：

biology; cancer; disease; human proteome project; proteomics; LASER-DESORPTION IONIZATION; PARAFFIN-EMBEDDED TISSUE; PROSTATE-SPECIFIC ANTIGEN; HUMAN BREAST-CANCER; COLORECTAL-CANCER; OVARIAN-CANCER; HUMAN-DISEASE; MALDI-MS; QUANTITATIVE PROTEOMICS; INTERACTOME NETWORKS;

D O I：

10.1586/14789450.2015.1040770

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The Human Proteome Project stands to eclipse the Human Genome Project in terms of scope, content and interpretation. Its outputs, in conjunction with recent developments across the proteomics community, provide new tools for cancer research with the potential of providing clinically relevant insights into the disease. These collectively may guide the development of future diagnosis, surveillance and treatment strategies. Having established a robust organizational framework within the international community, the Human Proteome Organization and the proteomics community at large have made significant advances in biomarker discovery, detection, molecular imaging and in exploring tumor heterogeneity. Here, the authors discuss some developments in cancer proteomics and how they can be implemented to reduce the global burden of the disease.

引用

页码：279 / 293

页数：15

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