A ratiometric fluorescent molecular probe for visualization of mitochondrial temperature in living cells

被引：127

作者：

Homma, Mitsumasa ^{[1
]}

Takei, Yoshiaki ^{[1
]}

Murata, Atsushi ^{[1
]}

Inoue, Takafumi ^{[1
]}

Takeoka, Shinji ^{[1
]}

机构：

[1] Waseda Univ, Grad Sch Adv Sci & Engn, Dept Life Sci & Med Biosci, Shinjuku Ku, Tokyo 1628480, Japan

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 28期

关键词：

THERMOMETRY;

D O I：

10.1039/c4cc10349a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mitochondrial thermodynamics is the key to understand cellular activities related to homeostasis and energy balance. Here, we report the first ratiometric fluorescent molecular probe (Mito-RTP) that is selectively localized in the mitochondria and visualize the temperature. We confirmed that Mito-RTP could work as a ratiometric thermometer in a cuvette and living cells.

引用

收藏

页码：6194 / 6197

页数：4

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