Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins

被引：23

作者：

Cao, Yanlu ^{[1
]}

Li, Bo ^{[1
,2
]}

Ismail, Nafissa ^{[3
,4
]}

Smith, Kevin ^{[3
]}

Li, Tianmei ^{[1
,2
]}

Dai, Rongji ^{[1
]}

Deng, Yulin ^{[1
]}

机构：

[1] Beijing Inst Technol, Sch Life Sci, Beijing Key Lab Separat & Anal Biomed & Pharmaceu, Beijing 100081, Peoples R China

[2] Beijing Inst Technol, Adv Res Inst Multidisciplinary Sci, Beijing 100081, Peoples R China

[3] Univ Ottawa, Fac Social Sci, Sch Psychol, Neuroimmunol Stress & Endocrinol NISE Lab, Ottawa, ON K1N 6N5, Canada

[4] Univ Ottawa, Brain & Mind Res Inst, Ottawa, ON K1N 6N5, Canada

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 23期

基金：

英国科研创新办公室;

关键词：

endogenous neurotoxins; neurotoxicity; neurodegenerative diseases; mechanism of action; N-METHYL-NORSALSOLINOL; INDUCED ANIMAL-MODELS; PARKINSONS-DISEASE; OXIDATIVE STRESS; TETRAHYDROISOQUINOLINE DERIVATIVES; DOPAMINERGIC NEUROTOXIN; IN-VIVO; REGIONAL-DISTRIBUTION; TYROSINE-HYDROXYLASE; HOMOVANILLIC-ACID;

D O I：

10.3390/ijms222312805

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endogenous and exogenous neurotoxins are important factors leading to neurodegenerative diseases. In the 1980s, the discovery that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) contributes to Parkinson's disease (PD) symptoms led to new research investigations on neurotoxins. An abnormal metabolism of endogenous substances, such as condensation of bioamines with endogenous aldehydes, dopamine (DA) oxidation, and kynurenine pathway, can produce endogenous neurotoxins. Neurotoxins may damage the nervous system by inhibiting mitochondrial activity, increasing oxidative stress, increasing neuroinflammation, and up-regulating proteins related to cell death. This paper reviews the biological synthesis of various known endogenous neurotoxins and their toxic mechanisms.

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页数：19

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