Neurotoxicity and Underlying Mechanisms of Endogenous Neurotoxins

被引：23

作者：

Cao, Yanlu ^{[1
]}

Li, Bo ^{[1
,2
]}

Ismail, Nafissa ^{[3
,4
]}

Smith, Kevin ^{[3
]}

Li, Tianmei ^{[1
,2
]}

Dai, Rongji ^{[1
]}

Deng, Yulin ^{[1
]}

机构：

[1] Beijing Inst Technol, Sch Life Sci, Beijing Key Lab Separat & Anal Biomed & Pharmaceu, Beijing 100081, Peoples R China

[2] Beijing Inst Technol, Adv Res Inst Multidisciplinary Sci, Beijing 100081, Peoples R China

[3] Univ Ottawa, Fac Social Sci, Sch Psychol, Neuroimmunol Stress & Endocrinol NISE Lab, Ottawa, ON K1N 6N5, Canada

[4] Univ Ottawa, Brain & Mind Res Inst, Ottawa, ON K1N 6N5, Canada

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 23期

基金：

英国科研创新办公室;

关键词：

endogenous neurotoxins; neurotoxicity; neurodegenerative diseases; mechanism of action; N-METHYL-NORSALSOLINOL; INDUCED ANIMAL-MODELS; PARKINSONS-DISEASE; OXIDATIVE STRESS; TETRAHYDROISOQUINOLINE DERIVATIVES; DOPAMINERGIC NEUROTOXIN; IN-VIVO; REGIONAL-DISTRIBUTION; TYROSINE-HYDROXYLASE; HOMOVANILLIC-ACID;

D O I：

10.3390/ijms222312805

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endogenous and exogenous neurotoxins are important factors leading to neurodegenerative diseases. In the 1980s, the discovery that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) contributes to Parkinson's disease (PD) symptoms led to new research investigations on neurotoxins. An abnormal metabolism of endogenous substances, such as condensation of bioamines with endogenous aldehydes, dopamine (DA) oxidation, and kynurenine pathway, can produce endogenous neurotoxins. Neurotoxins may damage the nervous system by inhibiting mitochondrial activity, increasing oxidative stress, increasing neuroinflammation, and up-regulating proteins related to cell death. This paper reviews the biological synthesis of various known endogenous neurotoxins and their toxic mechanisms.

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页数：19

相关论文

共 118 条

[11]

Dajas F., 1994, ELLIS HORWOOD SER NE, V64, P1425

[12] Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells -: protection by carbonyl scavengers [J].

de Arriba, Susana Garcia ;

Stuchbury, Grant ;

Yarin, Jennifer ;

Burnell, Jim ;

Loske, Claudia ;

Muench, Gerald .

NEUROBIOLOGY OF AGING, 2007, 28 (07) :1044-1050

[13] Localization of N-methyl-norsalsolinol within rodent and human brain [J].

DeCuypere, Michael ;

Kalabokis, Vassilios N. ;

Hao, Ruyi ;

Schroeder, Dorothy ;

Miller, Duane D. ;

LeDoux, Mark S. .

JOURNAL OF NEUROSCIENCE RESEARCH, 2008, 86 (11) :2543-2552

[14] Regional distribution of tetrahydroisoquinoline derivatives in rodent, human, and parkinson's disease brain [J].

DeCuypere, Michael ;

Lu, Yan ;

Miller, Duane D. ;

LeDoux, Mark S. .

JOURNAL OF NEUROCHEMISTRY, 2008, 107 (05) :1398-1413

[15] Neuroprotective Effect of Myxobacterial Extracts on Quinolinic Acid-Induced Toxicity in Primary Human Neurons [J].

Dehhaghi, Mona ;

Tan, Vanessa ;

Heng, Benjamin ;

Braidy, Nady ;

Mohammadipanah, Fatemeh ;

Guillemin, Gilles J. .

NEUROTOXICITY RESEARCH, 2019, 35 (02) :281-290

[16] DETERMINATION OF THE (R)-ENANTIOMERS AND (S)-ENANTIOMERS OF SALSOLINOL AND N-METHYLSALSOLINOL BY USE OF A CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC COLUMN [J].

DENG, YL ;

MARUYAMA, W ;

DOSTERT, P ;

TAKAHASHI, T ;

KAWAI, M ;

NAOI, M .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1995, 670 (01) :47-54

[17] Occurrence and distribution of salsolinol-like compound, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ADTIQ) in Parkinsonian brains [J].

Deng, Yulin ;

Zhang, Yongqian ;

Li, Yujuan ;

Xiao, Shengyuan ;

Song, Dewei ;

Qing, Hong ;

Li, Qin ;

Rajput, Ali H. .

JOURNAL OF NEURAL TRANSMISSION, 2012, 119 (04) :435-441

[18] (R)-Salsolinol, a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake [J].

Elena Quintanilla, Maria ;

Rivera-Meza, Mario ;

Berrios-Carcamo, Pablo ;

Cassels, Bruce K. ;

Herrera-Marschitz, Mario ;

Israel, Yedy .

ADDICTION BIOLOGY, 2016, 21 (06) :1063-1071

[19] Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates [J].

Elfarrash, Sara ;

Jensen, Nanna Moller ;

Ferreira, Nelson ;

Betzer, Cristine ;

Thevathasan, Jervis Vermal ;

Diekmann, Robin ;

Adel, Mohamed ;

Omar, Nisreen Mansour ;

Boraie, Mohamed Z. ;

Gad, Sabry ;

Ries, Jonas ;

Kirik, Deniz ;

Nabavi, Sadegh ;

Jensen, Poul Henning .

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2019, 7 (01)

[20] Pyridine-2,3-dicarboxylate, quinolinic acid, induces 1N4R Tau amyloid aggregation in vitro: Another evidence for the detrimental effect of the inescapable endogenous neurotoxin [J].

Esmaeili, Sajjad ;

Ghobadi, Nazanin ;

Akbari, Vali ;

Moradi, Sajad ;

Shahlaie, Mohsen ;

Ghobadi, Sirous ;

Jalalvand, Ali Reza ;

Amani, Mojtaba ;

Khodarahmi, Reza .

CHEMICO-BIOLOGICAL INTERACTIONS, 2020, 315

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