Walsucochins A and B with an unprecedented skeleton isolated from Walsura cochinchinensis

被引：38

作者：

Zhou, Zhi-Wang ^{[1
]}

Yin, Sheng ^{[1
]}

Zhang, Hai-Yan ^{[1
]}

Fu, Yan ^{[1
]}

Yang, Sheng-Ping ^{[1
]}

Wang, Xiao-Ning ^{[1
]}

Wu, Yan ^{[1
]}

Tang, Xi-Can ^{[1
]}

Yue, Jian-Min ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 03期

关键词：

D O I：

10.1021/ol702831e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Walsucochins A (1) and B (2) with an unprecedented skeleton were isolated from Walsura cochinchinensis. Their structures including absolute configuration were elucidated by spectral methods. A biosynthetic pathway of 1 and 2 was postulated. Both 1 and 2 exhibited significant cell protecting activities against H2O2-induced PC12 cell damage.

引用

页码：465 / 468

页数：4

共 17 条

[1] Balakrishna K., 1995, Fitoterapia, V66, P548
[2] Balakrishna K., 2003, Natural Product Sciences, V9, P192
[3] STRUCTURE OF WALSURENOL A NEW PENTACYCLIC TRITERPENE ALCOHOL FROM WALSURA TUBULATA
CHATTERJEE, A
KUNDU, AB
[J]. CHEMICAL COMMUNICATIONS, 1968, (07) : 418 - +
[4] Chen S. K., 1997, FLORA CHINA, V43, P62
[5] Dewick P.M., 2004, MED NATURAL PRODUCTS, P15
[6] TRITERPENOIDS FROM WALSURA-PISCIDIA
GOVINDACHARI, TR
KUMARI, GNK
SURESH, G
[J]. PHYTOCHEMISTRY, 1995, 39 (01) : 167 - 170
[7] A METHOD FOR DETERMINING CHIRALITY OF 2 AROMATIC CHROMOPHORES AND ABSOLUTE CONFIGURATIONS OF CHROMOMYCIN A3 AND RELATED ANTIBIOTICS
HARADA, N
NAKANISHI, K
TATSUOKA, S
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1969, 91 (21) : 5896 - +
[8] Tetranortriterpenoids from Walsura yunnanensis
Luo, XD
Wu, SH
Ma, YB
Wu, DG
[J]. JOURNAL OF NATURAL PRODUCTS, 2000, 63 (07): : 947 - 951
[9] Mitochondrial oxidative stress and inflammation:: an slalom to obesity and insulin resistance
Martinez, J. A.
[J]. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2006, 62 (04) : 303 - 306
[10] Oxidative stress in patients with non-complicated malaria
Pabón, A
Carmona, J
Burgos, LC
Blair, S
[J]. CLINICAL BIOCHEMISTRY, 2003, 36 (01) : 71 - 78

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