Eukaryotic origins of DNA replication: could you please be more specific?

被引：69
作者：
Cvetic, C [1 ]
Walter, JC [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 03期
关键词：
ORC; origins; DNA replication; cell cycle; initiation;
D O I：
10.1016/j.semcdb.2005.02.009
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Initiation of eukaryotic DNA replication commences when the origin recognition complex (ORC) binds to DNA, recruiting helicases, polymerases, and necessary cofactors. While the biochemical mechanism and factors involved in replication initiation appear to be highly conserved, the DNA sequences at which these events take place in different organisms are not. Thus, while ORC appears to bind to specific DNA sequences in budding yeast, there is increasing new evidence that metazoan ORC complexes do not rely oil sequence to be directed to origins of replication. Here, we review examples of specific and non-specific initiation, and we consider what, if not DNA sequence, accounts for DNA binding of ORC to defined regions in eukaryotic genomes. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：343 / 353
页数：11
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