GC-MS quantitation of fragrance compounds suspected to cause skin reactions. 1

被引：60
作者：
Chaintreau, A
Joulain, D
Marin, C
Schmidt, CO
Vey, M
机构：
[1] Int Fragrance Assoc, Analyt Working Grp, B-1000 Brussels, Belgium
[2] Firmenich Co, CH-1211 Geneva 8, Switzerland
[3] Robertet SA, F-06131 Grasse, France
[4] Symrise, D-38112 Braunschweig, Germany
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2003年 / 51卷 / 22期
关键词：
allergen; GC-MS; quantitation; skin reaction; fragrances; perfumes;
D O I：
10.1021/jf030363t
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
Recent changes in European legislation require monitoring of 24 volatile compounds in perfumes as they might elicit skin sensitization. This paper reports a GC-MS quantitation procedure for their determination in fragrance concentrates. GC and MS conditions were optimized for a routine use: analysis within 30 min, solvent and internal standard selection, and stock solution stability. Calibration curves were linear in the range of 2-100 mg/L with coefficients of determination in excess of 0.99. The method was tested using real perfumes spiked with known amounts of reference compounds.
引用
收藏
页码：6398 / 6403
页数：6
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