Fabrication of Centrifugal Microfluidic Solid Phase Extraction Devices and Its Application in Chromium Speciation Analysis

The analysis of environmental samples can be enhanced by the combination of solid phase extraction, centrifugal microfluidic with inductively coupled plasma mass spectrometry ( ICP-MS). In this study, a five layers centrifugal microfluidic device was design and fabricated with studying the method of preparation of solid phase extraction column. Cr(III) and Cr(VI) were separated on this device, and ICP-MS was used for detecting total Cr and non-absorbed Cr(VI) in solution. The system could process up to 8 samples simultaneously in short time, providing easy to use. This procedure allows for a rapid and good separation and quantification, only 100 L of sample and reagents was used, and the detection limit for Cr(VI) is 2 g/L.