High-Throughput Doppler Toolbox for Preclinical Drug Development

被引：1

作者：

Azer, Karim ^{[1
]}

Desiderio, Michael C. ^{[1
]}

Tong, Christopher

Bunzel, Michelle ^{[2
]}

Campbell, Barry R. ^{[2
]}

Shevell, Diane ^{[3
]}

Walker, Matthew, III ^{[2
]}

机构：

[1] Merck & Co Inc, Dept Appl Comp Sci & Math, Rahway, NJ 07065 USA

[2] Merck & Co Inc, Dept Imaging Res, Rahway, NJ 07065 USA

[3] Merck & Co Inc, Dept Immunol, Rahway, NJ 07065 USA

来源：

JALA | 2010年 / 15卷 / 04期

关键词：

Doppler ultrasound; drug development; hemodynamics; automated analysis; blood flow; biomarkers; AORTIC BLOOD VELOCITY; ESOPHAGEAL DOPPLER; PERFORMANCE;

D O I：

10.1016/j.jala.2009.12.002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Quantification of hemodynamics may be invaluable in a drug development setting. However, one of the challenges in the application of imaging technologies for compound screening purposes is the large volume of data in a short amount of time. This article focuses on methods developed for large-scale hemodynamic quantification, as measured from high-frequency Doppler ultrasound in rodents. An integrative semiautomated method for processing Doppler ultrasound images is described and validated. In the context of experimental biology, this toolbox allows for a comprehensive hemodynamic evaluation of in vivo physiology as the result of medical intervention, thus enabling rapid compound screening in preclinical drug development. (JALA 2010;15:287-96)

引用

页码：287 / 296

页数：10

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